Castleman病临床特征与诊疗分析

Clinicopathological characteristics, diagnosis and treatment of Castleman＇s disease

目的 探讨Castleman病的临床表现,CT、病理学特征,诊断、治疗与预后.方法 通过对17例经手术及病理证实的Castleman病的病例分析,结合文献复习,对本病的病因、临床表现、CT、病理、诊断、治疗及预后,尤其Castleman病伴副肿瘤性天疱疮的临床表现、治疗进行综合分析与讨论.结果 本组病例男10例,女7例,年龄28～ 56岁,均为局灶型,病理分型均为透明血管型.手术治疗均治愈.结论 Castleman病是一种罕见的淋巴组织增生性疾病.其诊断依赖于病理组织学形态,并须结合其临床资料.治疗方面,手术切除是首选.

Objective To explore the clinicopathological characteristics, diagnosis and treatment of Castleman＇s disease. Methods Seven teen cases of castleman＇s disease confirmed by surgery and pathology were presented, with the helping of relevant literatures, to discuss its clinical presentation, CT findings, pathology,diagnosis,treatment and prognosis, especially the cases with PNP. Results There were l O males and 7 females with an age range of 28 - 56 years. They were all of local hyaline-vascular types according to histopathology. All cases were cured by surgical resection. Conclusions Castleman＇s disease is a rare lyphoproliferative disorder with giant lymph node hyperplasia. Its diagnosis depends on its histopathological characteristics and clinical manifestations should also be taken into account. Surgical resection is the first choice and other treatments may be effective.