幽门螺杆菌感染患儿全血微量元素检查的必要性

Necessity of monitoring blood trace elements in children with Helicobacter pylori infection

目的:探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染患儿全血微量元素水平,及微量元素在H.pylori感染患儿治疗中的价值.-方法:80例非H.pylori感染患儿作为对照组,,80例H.pylori感染患儿作为观察组,观察组患儿接受三联疗法治疗,疗程为2 wk;其中接受三联疗法的同时针对不同患儿出现的微量元素缺乏情况进行锌或铁微量元素补充的对症治疗的40例患儿为观察1组,另外40例患儿接受三联疗法同时均给予锌和铁微量元素补充.对比观察组和对照组微量元素锌、铁、铜、钙、镁水平、贫血发生情况.治疗1 mo后对观察组两亚组患儿H.pylori感染、微量元素、贫血情况.结果:(1)微量元素检查结果显示:观察组患儿锌、铁水平高于对照组(P<0.05);铜、钙、镁组间比较差异无统计学意义(P>0.05);(2)观察组锌、铁元素缺乏者比例明显高于对照组(31.25%vs 13.75%,36.25%vs 17.50%,P<0.01),其他元素缺乏患儿比例组间差异无统计学意义(P>0.05);(3)观察组患儿贫血发生率高于对照组(40.00%vs 18.75%,P<0.01);(4)观察组患儿经不同治疗方案治疗1 mo后,观察2组患儿缺锌、缺铁、H.pylori阳性、贫血例数均低于观察1组(5 vs 16,2 vs 13,3 vs 11,1vs 6,P<0.05或P<0.01).结论:H.pylori感染患儿可能存在锌、铁微量元素缺乏的现象,缺铁性贫血发生率高,治疗期间,给予H.pylori感染患儿锌、铁补充有利于患儿恢复,建议H.pylori感染患儿给予微量元素补充.

AIM： To analyze the blood trace elements necessity of monitoring in children with Helico- bacter pylori （H. pylori） infection, and assess the value of trace elements in the treatment of chil- dren with H. pylori infection. METHODS： Eighty children without H. pylori infection （control group） and 80 children with H. pylori infection （observation group） were in- cluded. The children in the observation group all accepted triple therapy for two weeks, of whom 40 additionally accepted symptomatic treatment by zinc or iron supplementation （symptomatic treatment subgroup）, and another 40 received simultaneous supplementation of zinc and iron （non-symptomatic treatment subgroup）. The lev- els of zinc, iron, copper, calcium and magnesium and the incidence of anemia were compared be-tween the observation group and control group, and H. pylori infection, trace elements, and ane- mia were compared between the two subgroups after I mo of treatment. RESULTS： Zinc and iron levels were signifi- cantly higher in the observation group than in the control group （P 〈 0.05）, although there were no statistically differences in copper, calcium or magnesium levels between the two groups （P 〉 0.05）. In the observation group, the percentages of children with zinc or iron deficiency were sig- nificantly higher than those in the control group （31.25% vs 13.75%, 36.25% vs 17.50%, P 〈 0.01）, although the percentages of children with defi- ciency of other elements had no significant dif- ferences （P 〉 0.05）. The incidence of anemia was significantly higher in the observation group than in the control group （40.00% vs 18.75%, P 〈 0.01）. The numbers of children with zinc defi- ciency, iron deficiency, H. pylori infection or ane- mia were significantly lower in the symptomatic treatment subgroup than in the non-symptomat- ic treatment subgroup （5 vs 16, 2 vs 13, 3 vs 11, 1 vs 6, P 〈 0.05 or P 〈 0.01）. CONCLUSION： H. pylori infection children may develop zinc or iron deficiency and have a higher incidence of iron-deficiency anemia. Zinc or iron supplementation during H. pylori eradi- cation treatment is conducive to recovery in H. pylori infection children.