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硼替佐米治疗多发性骨髓瘤致急性肺损伤 被引量:3

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摘要 患者 男性,72岁.因"自觉胸部疼痛6个月+"于2013-02-21入本院.病史采集:患者既往患慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)6年+.入院查体:桶状胸,双肺触觉语颤正常对称,听诊呼吸音稍低,未闻及干湿哕音及胸膜摩擦音;余未见异常.辅助检查结果示:骨髓浆细胞占25%,尿中本周蛋白κ链>1 g/24 h,血β2微球蛋白为3.66 mg/L,血清蛋白为30 g/L,血肌酐为104.6 μmol/L,胸部及头部X射线摄片结果未见溶骨性病变.入院诊断为:多发性骨髓瘤(multiple myeloma,MM)ⅡA期(轻链型).入院后,予患者:硼替佐米(bortezomib,B)2.5 mg(1.3 mg/m^2),d1;3.5 mg,d4;3.5 mg,d10+地塞米松(dexamethasone,D) 30 mg,d1,4,8,11+沙利度胺(thalidomide,T)100mg,d1~28(即BTD化疗方案).
出处 《国际输血及血液学杂志》 CAS 2014年第5期467-468,共2页 International Journal of Blood Transfusion and Hematology
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参考文献13

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二级参考文献20

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共引文献13

同被引文献19

  • 1王亚非,邱录贵,邹德慧,王迎,邓书会,李园,徐燕,钱林生,赵耀中.硼替佐米治疗多发性骨髓瘤后严重肺损伤二例报告并文献复习[J].白血病.淋巴瘤,2008,17(2). 被引量:12
  • 2急性肺损伤/急性呼吸窘迫综合征诊断和治疗指南(2006)[J].中国实用外科杂志,2007,27(1):1-6. 被引量:198
  • 3Chauhan D, Hideshima T, Anderson KC. Proteasome inhibition in multiple myeloma: therapeutic implication [ J ]. Annu Rev Phar-maeol Toxicol, 2005,45:465 -476.
  • 4Fujisawa M, Suehara Y, Fukumoto K, et al. Changes in survival rate of multiple myeloma after the introduction of bortezomib: a single institutional experience over 20 years [ J ]. Ann Hematol, 2015,84(689) :1 - 10.
  • 5Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma [ J]. N Engl J Med, 2003,348(26) :2609 -2617.
  • 6Miyakoshi S, Kami M, Yuji K, et al. Severe pulmonary complica- tions in Japanese patients after bortezomib treatment for refractory multiple myeloma [ J ]. Blood, 2006,107 ( 9 ) : 3492 - 3494.
  • 7Min CK, Lee S, Kim YJ, et al. Cutaneous leucoclastic vasculitis (LV) following bortezomib therapy in a myeloma patient; associ- ation with pro - inflammatory cytokines [ J ]. Eur J Haematol, 2006,76(3 ) :265 - 268.
  • 8Pitini V, Arrigo C, Ahavilla G, et al. Severe pulmonary compli- cations after bortezomib treatment for multiple myeloma: an un- recognized pulmonary vasculitis? [ J]. Leuk Res, 2007,31 (7) : 1027 - 1028.
  • 9顿晓熠,袁振刚,傅卫军,侯健.硼替佐米治疗多发性骨髓瘤致五例患者严重肺损伤[J].中华血液学杂志,2010,31(4):259-261. 被引量:9
  • 10魏永强,刘启发,张钰,孙竞,孟凡义.硼替佐米治疗多发性骨髓瘤致肺损伤1例并文献复习[J].南方医科大学学报,2010,30(5):1177-1179. 被引量:1

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