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青少年特发性脊柱侧凸交感神经系统活性左右侧对称性的观察 被引量:7

The asymmetry of the activity of sympathetic nervous system in the patients with adolescent idiopathic scoliosis
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摘要 目的:探讨交感神经系统(sympathetic nervous system,SNS)活性在AIS病因学中可能存在的作用。方法:前瞻性研究。纳入68例右胸弯AIS女性患者为观察对象,年龄11~18岁,平均14.2±2.4岁;主弯Cobb角11°~64°,平均37.2°±13.5°。选取5例青少年先天性脊柱侧凸(CS)女性患者和28例正常年轻女性作为对照,CS患者年龄12~18岁,平均14.7±3.1岁;正常年轻女性11~22岁,平均17.9±4.0岁。采用交感神经皮肤反应(sympathetic skin response,SSR)评估3组的SNS活性,以上下肢潜伏期和振幅右侧/左侧的比值作为评估指标。组间及组内比较采用独立样本t检验,P<0.05为差异有统计学意义。结果:正常年轻女性组中,上下肢潜伏期和振幅右/左比值在正常青少年(13.6±2.8岁,11~17岁)和年轻女性(20.7±1.2岁,19~22岁)间无显著性差异(P>0.05)。女性AIS患者上肢潜伏期右侧/左侧比值(1.01±0.05)显著性大于正常年轻女性(0.98±0.04,P=0.036),上肢振幅、下肢潜伏期和下肢振幅右侧/左侧比值在女性AIS患者与正常年轻女性间无显著性差异(P>0.05)。CS患者上、下肢潜伏期和振幅的右侧/左侧比值与正常年轻女性间无显著性差异(P>0.05);女性AIS患者上、下肢潜伏期和振幅右侧/左侧比值在小角度(<40°)和大角度(≥40°)间亦无显著性差异(P>0.05)。结论:女性AIS患者身体两侧SNS活性存在不对称性,其可能与发病有关,但是与侧凸的严重程度无显著相关性。 Objectives: To explore the probable associations of the sympathetic nervous system(SNS) activity with the etiology in adolescent idiopathic scoliosis (AIS). Methods: A prospective study including 68 right thoracic AIS female patients, 5 congenital scoliosis (CS) and 28 healthy girls with a mean age of 14.2+2.4y (ll-18y), 14.7_+3.1y(12-18y) and 17.9_+4.0y(ll-22y), respectively was carried out. The mean Cobb angle of major curve in AIS was 37.2~+13.5^(11^-64^). The asymmetry of SNS activity was presented by the fight/left (R/L) ratios of latency and the amplitude of sympathetic skin response (SSR) obtained in upper and lower limbs. Student's t test was used in inter- and intra-group comparisons. A statistically significant difference was defined by P〈0.05. Results: In the normal control group, there was no significant difference in the L/R ratios of latency and amplitude of SSR in upper and lower limbs between adolescents(13.6+2.8y, l l-17y) and young adults(20.7~l.2y, 19-22y)(P〉O.05). The R/L ratios of the latency in AIS upper limbs(1.01_+0.05) were significantly greater than those in normal controls(0.98_+0.04, P=0.036), which indicated that the symmetry of the SNS activities in AIS was significantly different from that in normal controls; while there were no significant differences in the R/L ratios of the upper limb amplitude, lower limb latency and lower limb amplitude between AIS and normal controls(P〉0.05). Moreover, there was no significant difference in the R/L ratios of the latency and amplitude between normal controls and CS (P〉0.05); meanwhile,
出处 《中国脊柱脊髓杂志》 CAS CSCD 北大核心 2014年第10期923-927,共5页 Chinese Journal of Spine and Spinal Cord
基金 南京市医学科技发展资金资助项目(JQX12005)
关键词 青少年特发性脊柱侧凸 交感神经系统 交感神经皮肤反应 Adolescent idiopathic scoliosis Sympathetic nervous system Sympathetic skin response
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