慢性乙型肝炎及早期肝硬化患者血清谷氨酰转肽酶活性变化的初步探讨

The preliminary discussion of changes of serumγ-GT level in patients with chronic hepatitis B and early liver cirrhosis

目的探讨血清谷氨酰转肽酶(gamma-glutamyl transferase,γ-GT)活性在慢性乙型肝炎(CHB)及早期肝硬化患者不同程度肝脏病理损害中的变化规律及临床意义。方法测定105例CHB和LC患者血清ALT、AST、γ-GT水平,同时行肝活组织检查,对肝脏进行炎症分级(G)和纤维分期(S)。分析ALT、AST、γ-GT与G和S之间的关系。结果γ-GT异常数随着肝脏炎症级别和肝脏纤维化级别的上升而明显,分别P<0.05(卡方值4.477a)和P<0.01(Fisher值17.282)。结论血清γ-GT能准确地反映出肝脏炎症和纤维化的程度,γ-GT的活性为临床判断慢乙肝的炎症和纤维化程度提供了重要的依据。

Objective To preliminarily discuss the change rules and clinical significance of serum γ-GT level in varying degrees of liver pathological damage among in-patients with chronic hepatitis B （CHB）and early liver cirrhosis. Methods Serum ALT,AST and γ-GT levels were detected in 80 in-patients with CHB and early liver cirrhosis, respectively.Meanwhile, liver inflammatory grading and staging of fibrosis were investigated by hepatic biopsy. Relationship between serum ALT,AST,γ-GT levels and liver inflammatory grading （G）,fiber staging （S）was analyzed. Results Serum γ-GT level was increased with the degree of liver inflammatory grading （G）and fibrosis staging （S）,and a significantly positive linear correlation was observed （χ2 =4.477a,Fisher=17.282,P＆lt;0.05 ）.Conclusions Serum γ-GT level can more accurately reflect the degree of liver inflammation and fibrosis than those of serum ALT and AST levels. Serum γ-GT level is more closely related with liver fibrosis degree.γ-GT activity provides an important basis to clinically judge the inflammation and fibrosis in CHB patients.