NLRP1在血液疾病中作用的研究进展

Roles of NLRP1 in Blood Diseases——Review

炎性复合体是存在于胞浆中的一组多蛋白复合体,它能够活化胱天蛋白酶(caspase)-1,后者介导IL(interleukin)-1β、IL-18和IL-33等促炎因子的成熟与释放。NALP1(NACHT leucine-rich-repeat protein 1)也称NLRP1,是最早被鉴定出来的具有明确配体的炎性复合体之一,它参与多种炎症反应和细胞凋亡的调节作用。此外,还有研究发现NLRP1在急性白血病的发生发展及诱导骨髓造血干细胞凋亡等血液系统疾病中也发挥着重要作用。本文将对NLRP1的结构、活化机制、调控及在造血系统中的作用进行综述。

The inflammasome is a group of multiprotein complexes in the cytoplasm,which can activate caspase-1 that mediates the maturation and release of IL-1β,IL-18,IL-33 and other pro-inflammatory cytokines.NALP1 （NACHT leucine-rich-repeat protein 1）,also known as NLRP1,is the first one of the identified complex inflammasomes with definite ligands mainly involved in the activation of inflammasome assembly and the formation of apoptotic bodies.Moreover,it was also found that NLRP1 plays an important biological role in the development of acute leukemia,the bone marrow hematopoietic stem cell apoptosis and other blood diseases.This review briefly summarizes the structure,activation mechanism,regulation and the role of NLRP1 in the hematopoietic system.