摘要
目的本研究通过对352名参与者进行5年的随访,探讨成纤维细胞生长因子(FGF-21)与代谢综合征(MS)发生发展的关系。方法记录参与者一般临床资料,采用酶联免疫吸附法(ELISA)测定基线及随访5年后参与者血清FGF-21浓度水平,对比分析MS组与非MS组间FGF21浓度水平的差异,并采用多因素Logistic回归分析FGF21是否为MS的独立危险因素。结果 MS组参与者基线FGF21浓度水平明显高于非MS组,差异有统计学意义(P<0.05);MS组参与者随访5年后FGF21浓度水平明显高于基线FGF21浓度水平,差异有统计学意义(P<0.05),非MS组参与者随访5年后血清FGF21浓度水平与基线FGF21浓度水平差异无统计学意义(P>0.05);多因素Logistic回归分析发现,腰围、BMI、TG、HOMA-IR、FGF21是影响MS发生的独立危险因素。结论血清FGF-21浓度水平高是MS发生的独立危险因素,未来有可能成为干预MS有效的分子靶点。
Objective To investigate the prospective association of fibroblast growth factor 21(FGF21)with metabolic syndrome(MS)development in a 5-year prospective study involving a population-based cohort comprising 352 Chinese subjects. Methods The clinical data of subjects were recorded:serum FGF21 levels at baseline and follow-up were measured using an enzyme-linked immunosorbent assay. Whether FGF21 was independent predictor of MS development were identified using logistic regressions. Results Serum FGF21 levels of MS group were significantly higher than those of non-MS group(P〈0.05).At follow-up,significant increase of FGF21 level was observed in those subjects who developed MS(P〈0.05),but in non- MS group,there was no significant difference of FGF21 level between baseline and follow-up.We found that BMI,TC,HOMA-IR and FGF21 were independent predictors of MS through logistic regressions. Conclusions High FGF21 levels was independent predictor of MS. It may be useful for early diagnosis and intervention of MS.
出处
《热带医学杂志》
CAS
2014年第9期1159-1161,1185,共4页
Journal of Tropical Medicine