成纤维细胞生长因子21与代谢综合征的相关性研究

The association analysis of fibroblast growth factor 21 and metabolic syndrome

目的本研究通过对352名参与者进行5年的随访,探讨成纤维细胞生长因子(FGF-21)与代谢综合征(MS)发生发展的关系。方法记录参与者一般临床资料,采用酶联免疫吸附法(ELISA)测定基线及随访5年后参与者血清FGF-21浓度水平,对比分析MS组与非MS组间FGF21浓度水平的差异,并采用多因素Logistic回归分析FGF21是否为MS的独立危险因素。结果 MS组参与者基线FGF21浓度水平明显高于非MS组,差异有统计学意义(P<0.05);MS组参与者随访5年后FGF21浓度水平明显高于基线FGF21浓度水平,差异有统计学意义(P<0.05),非MS组参与者随访5年后血清FGF21浓度水平与基线FGF21浓度水平差异无统计学意义(P>0.05);多因素Logistic回归分析发现,腰围、BMI、TG、HOMA-IR、FGF21是影响MS发生的独立危险因素。结论血清FGF-21浓度水平高是MS发生的独立危险因素,未来有可能成为干预MS有效的分子靶点。

Objective To investigate the prospective association of fibroblast growth factor 21（FGF21）with metabolic syndrome（MS）development in a 5-year prospective study involving a population-based cohort comprising 352 Chinese subjects. Methods The clinical data of subjects were recorded：serum FGF21 levels at baseline and follow-up were measured using an enzyme-linked immunosorbent assay. Whether FGF21 was independent predictor of MS development were identified using logistic regressions. Results Serum FGF21 levels of MS group were significantly higher than those of non-MS group（P〈0.05）.At follow-up,significant increase of FGF21 level was observed in those subjects who developed MS（P〈0.05）,but in non- MS group,there was no significant difference of FGF21 level between baseline and follow-up.We found that BMI,TC,HOMA-IR and FGF21 were independent predictors of MS through logistic regressions. Conclusions High FGF21 levels was independent predictor of MS. It may be useful for early diagnosis and intervention of MS.