卵巢子宫内膜异位囊肿剥除术后体外受精胚胎移植临床结局的回顾

Clinical outcome of patients undergone IVF-ET after exeresis of ovarian endometrioma:a retrospective study

目的探讨卵巢子宫内膜异位囊肿剥除术后患者的体外受精-胚胎移植妊娠结局。方法回顾性分析2008年1月至2013年1月本院生殖医学中心卵巢子宫内膜异位囊肿剥除术后行长方案IVF-ET共132个周期,其中基础卵泡刺激素（FSH）≤10U/L的患者76个周期（A组）,基础FSH 10-15U/L的56个周期（B组）,同期基础FSH≤10U/L的单纯性输卵管性因素行长方案体IVF-ET共72个周期（C组）,比较3组治疗结局。结果获卵数和注射人绒毛膜促性腺激素（HCG）日血雌二醇（E2）水平,C组显著高于A组及B组;A组与B组比较,A组高于B组,差异均有统计学意义（P〈0.05）。促性腺激素（Gn）量C组显著低于A组及B组;A组与B组比较,A组低于B组,差异均有统计学意义（P〈0.05）。3组的年龄、体重指数（BMI）、基础E2、不孕年限、受精率、优胚率、Gn天数、妊娠率、种植率、流产率均无显著差异（P〉0.05）。结论卵巢子宫内膜异位囊肿剥除术后基础FSH≤10U/L患者与FSH值相当的输卵管因素患者行IVF的妊娠结局相似,但获卵数较少且Gn用量较高。

Objective： To analyze the IVF-ET outcomes in the patients after exeresis of ovarian endometrioma. Methods. The clinical outcomes was retrospectively evaluated for 132 cycles after previous exeresis of ovarian endometrioma from January 2008 to January 2013. Among them,there were 76 patients with lasal FSH levels %10 U/L in group A,and 56 patients with basal FSH levels 10-15 U/L in group B. There Were another 72 patients with simple tube factor infertility and basal FSH levels-10 U/L in group C. Results.. The patients＇ characteristics and the IVF treatment outcome parameters had no significant differences among the three groups（P-0.05）. However,the number of retrieved oocytes and the levels of E2on HCG day in group C were significantly higher than those in group A and group B（P〈0.05）. The amount of FSH used significantly higher in group B than that in other two groups,and that in group C was significantly less than in group A（P〈0.05）. Conclusions. In the patients undergone IVF-ET after exeresis of ovarian endometrioma, the low number of retrieved oocytes and higher amount of FSH consumption are found, though basal FSH levels are still low.