急性痛风性关节炎与血尿酸及尿酸盐结晶的关系

Relationship of Acute Gouty Arthritis with Uric Acid and Urate Crystals

目的:探讨急性痛风性关节炎与血尿酸及尿酸盐结晶之间的关系。方法:回顾性分析75例急性痛风性关节炎患者的一般资料、血尿酸值、尿酸盐结晶沉积部位计数;根据性别分为男女两组、根据血尿酸水平分为高血尿酸组和正常血尿酸组,采用SPSS 19.0统计软件进行统计分析。结果:年龄与血尿酸水平、尿酸盐结晶沉积部位计数均无相关性(P>0.05);尿酸盐结晶沉积部位计数与病程、血尿酸水平呈正相关(P<0.05);男性组血尿酸值(405.18±132.21)μmol/L,尿酸盐沉积部位(37.45±17.14)个,女性组血尿酸值(288.50±57.21)μmol/L,尿酸盐沉积部位(23.19±12.80)个,均存在差异(P<0.05);高血尿酸组尿酸盐结晶沉积部位(34.64±18.19)个,正常组尿酸盐结晶沉积部位(31.44±16.62)个,两组间无差异(P>0.05)。结论:急性痛风性关节炎发作是以尿酸盐结晶存在为基础,其发作期血尿酸值不一定高,尿酸盐结晶沉积部位计数与血尿酸呈正相关,但两者关系有待进一步研究。

Objective To explore the relationship of acute gouty arthritis with uric acid and urate crystals. Methods A retrospective analysis of 75 cases of acute gouty arthritis of general information, uric acid, urate crystal deposition site counts was made. Men and women were separately divided into two groups, basing on the blood uric acid level divided into high uric acid group and normal uric acid group, using SPSS 19.0 statistical software for statistical analysis. Results Age and uric acid, urate crystal deposition site counts were not corre-lated（P＆gt;0.05）; urate crystal deposition site counts were positively correlated with the duration and with serum uric acid levels （P〈0.05）. In the male group uric acid showed （405.18±132.21） μmol/L, urate crystal deposition site counts were （37.45±17.14）, while in the female group uric acid （288.50±57.21） μmol/L, urate crystal deposi-tion site counts （23.19 ± 12.80）, with significant differences （P〈0.05） According to uric acid groups, urate crys-tal deposition site were counts of high uric acid group （34.64 ± 18.19）, and normal uric acid group （31.44 ± 16.62） , with no differences （P＆gt;0.05）. Conclusion Acute gouty arthritis attack is based on the presence of urate crystals, their attack is not necessarily with high uric acid, urate crystal deposition site counts and uric ac-id are positively correlated, but the relationship needs further study.