脑膜瘤125例临床病理分析

Clinicopathological features of meningioma: an analysis of 125 cases

目的 回顾性分析125例脑膜瘤的临床病理特点,以提高对脑膜瘤的认识及诊断水平.方法 按照WHO （2007）中枢神经系统肿瘤分类中的标准对125例脑膜瘤进行病理分类及临床资料回顾性分析.结果 125例脑膜瘤中,女性88例（70.4％）,男性37例（29.6％）,男女之比为1：2.3.其中属低复发性和低进展危险性组脑膜瘤102例（81.6％）,高复发性和高进展危险性脑膜瘤23例（18.4％）;前者女性78例,后者10例;前者男性24例,后者13例;差异显著（P＜0.05）.男女两组的发病年龄高峰均在51 -60岁,随着年龄增大发病趋于相对稳定.男性组中,≤50岁者发生高复发和高进展危险性脑膜瘤的概率大于＞ 50岁者,差异显著（P＜0.05）,而＞50岁组发生低复发和低进展危险性脑膜瘤的概率大于≤50岁者,差异亦显著（P＜0.05）.而在女性组中,两个年龄段发生低级别或高级别脑膜瘤的概率差异不显著（P＞0.05）.病理组织学类型主要为内皮型（49/125）和纤维型（30/125）;发生部位多在大脑凸面,与大脑镰相连,其次为颅底部,再次为小脑、脑室及胸椎等部位.结论 脑膜瘤在性别、发病年龄、病变部位、病理学类型等方面具有一定的特点和规律,充分认识脑膜瘤的临床病理特点,可为早期发现和早期诊疗提供更充足的依据.

Objective To analyze the clinical and pathological features of 125 cases of meningioma and to improve the understanding and diagnosis of meningioma.Methods Application 2007 WHO classification of tumors of the central nervous system,pathological classification and clinical data were retrospectively analyzed in 125 cases of meningioma.Results In total 125 cases of meningioma,88 cases （70.4％） were female,37 cases （29.6％） male,male：female was 1：2.3.In 125 cases of meningiomas,there were 102 cases （81.6％） of low recurrence meningiomas,and 23 cases （18.4％） of high recurrence meningiomas.Where women were lower recurrence in 78 cases of meningioma,high recurrence meningiomas 10 cases; males were lower recurrence meningioma 24 cases,high recurrence of meningioma in 13 cases ; male and female difference was statistically significant （P ＜ 0.05）.Peak age groups for men and women were in the 51 to 60 age group,increased with age,the incidence tends to be relatively stable.Chance in the male group,≤50 years of relapse in patients with high-risk and high-progressive meningioma were greater than ＞ 50 years of age of onset patients,there were significant differences between the two groups （P ＜ 0.05）.In female patients,at ≤ 50 years of age and ＞ 50years age occurred probability of meningioma was no significant difference （P ＞ 0.05）.Main histological type was endothelial type 39.2 ％ （49/125） and fiber type accounted for 24.0％ （30/125） ; It most commonly occured in convex parts of the brain,linked to falx cerebri,followed by cranial base,the cerebellum,ventricle and thoracic spine and other parts.Conclusions Meningioma has certain characteristics in gender,age,lesion,pathology type,etc..We should try to fully understand the clinical and pathological features of meningioma,to provide a more adequate basis for early detection and early treatment.