组织细胞性坏死性淋巴结炎—附2例报告及文献复习

Histocytic Necrotizing Lymphadenitis: 2 Cases Report and Literature Review

目的结合文献探讨组织细胞性坏死性淋巴结炎的临床特征。方法报道2例组织细胞性坏死性淋巴结炎病例,并就本病的临床生物学特征、病因病理、诊断与鉴别诊断、治疗及预后进行分析。结果组织细胞性坏死性淋巴结炎是一种以细胞凋亡为病理特征的非特异性临床表现的淋巴系疾病。以区域性淋巴结肿大为主,易误诊。结论病理学诊断是唯一可靠依据。糖皮质激素治疗可见显著效果并缩短病程,抗生素和抗结核药物治疗无效。本病为自限性疾病,自然病程数周或数月,多数预后良好。

Objective To study the clinical characteristics of histocytic necrotizing lymphadenitis （HNL） and to review the correlative literatures.Methods Two patients admitted to our hospital were retrospectively studied, including the clinical features, histopathology, diagnosis, therapy and prognosis.Results HNL is a kind of disease of lymph system, and lymphadenopathy was the most common clinical manifestation. The pathology feature is cell apoptosis. It tends to be misdiagnosed.Conclusion The only diagnosis evidence is pathology diagnosis to HNL. Glucocorticord has better effect on HNL and can shorten the course of this disease. Those medicines of antibiotics and anti-tuberculosis have no therapeutic effect. HNL is a self-limited disease and has relatively well prognosis.