术前TPF诱导化疗在中晚期口腔鳞癌治疗中的初步评估

Preliminary evaluation of pre-operation induction chemotherapy with TPF for advanced oral squamous cell carcinoma

目的初步探讨术前TPF诱导化疗方案在口腔中晚期口腔鳞癌治疗中的临床疗效。方法 2008年6月至2010年6月48例中晚期口腔鳞癌患者接受TPF诱导化疗,化疗方案为D1多西他赛75 mg/m2,D1顺铂75 mg/m2,D1-D5 5-氟尿嘧啶(5-FU)750 mg/m2,以及相关的保护性用药,结束2个周期化疗后2周对疗效进行评价,应用化疗前定点液定点肿瘤边缘或参照CT/MRI影像学治疗前后对比评价效果,分为完全缓解(CR)、部分缓解(PR)、病灶稳定(SD)和疾病进展(PD),CR+PR计为有效病例。结果化疗结束2周后观察到CR 2例,PR 26例,SD 18例,PD 2例,有效率为58.33%(28/48),化疗期间内未见严重不良反应。结论 TPF诱导化疗可使中晚期口腔鳞癌瘤体体积明显缩小,近期效果显著,远期疗效有待进一步观察。

Objective To evaluate the clinical effect of pre-operation induction chemotherapy with TPF for advanced oral squamous cell carcinoma. Methods From June 2008 to June 2010,48 patients with advanced oral squamous cell carcinoma received induction chemotherapy （DI Docetaxel 75 mg/m：, D1 Cisplatin 75 mg/m2, D1-D5 5-fluorouracil 750 mg/m：）. Two week after two cycles of chemotherapy, the effects before and after chemotherapy were compared based on the tumor volume and the effects. All cases were divid- ed into complete response （CR） , partial response（PR） , stable disease（SD） and progressive disease（PD） , and CR ＋ PR were effective cases. Results The overall response rate was 58.33 % （28/48） with 2 cases of CR,26 cases of PR, 18 cases of SD and 2 cases of PD, with no serious adverse reactions. Conclusions Induction chemotherapy with TPF can decrease the tumor volume of advanced oral squamous cell carcinoma significantly. The short-term effects of this method are marked,while further observation will be needed for the evaluation of long-term effects.