他汀治疗对冠状动脉慢血流患者血清可溶性E-选择素、hs-CRP水平的影响

Effect of statins therapy on serum levels of soluble E-selectin and high sensitive C-reactive protein in patients with slow coronary flow

目的:了解较长时间的他汀治疗对冠状动脉慢血流(SCF)患者血清可溶性E-选择素(SES)以及高敏C反应蛋白(hs-CRP)水平的影响,评价他汀类药物在SCF患者治疗中的地位。方法:30例SCF患者,术后规范化服用常规剂量的他汀类药物治疗6个月,对患者治疗前后的血清低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、SES、hsCRP水平进行比较分析。结果:他汀治疗6个月后,SCF患者血清LDL-C[(3.48±2.03)mmol/L vs(2.59±1.91)mmol/L,P<0.05]、SES[(58.60±3.96)ng/mL vs(48.31±2.89)ng/mL,P<0.05]以及hs-CRP[(3.92±0.40)μg/mL vs(2.97±0.42)μg/mL,P<0.05]水平明显降低,HDL-C水平有一定程度的升高[(0.90±0.23)mmol/L vs(1.01±0.18)mmol/L,P>0.05]。结论:他汀治疗可明显降低SCF患者低强度炎症反应因子血清SES以及hs-CRP水平。

Objective ： To understand the effect of long term statins therapy on serum levels of high sensitive C-reactive protein （hs-CRP） and soluble E-selectin （SES） in patients with slow coronary flow （SCF）. Methods ： Thirty patients with SCF were treated with routine dose of statins drugs for 6 months. The patientslow density lipoprotein-eholesterol （LDL-C）, high density lipoprotein-eholesterol （HDL-C） , serum levels of hs-CRP and SES were compared and analyzed after 6 months follow-up. Results ： The serum levels of LDL-C [ （ 3.48 ± 2.03 ） mmoL/L vs （ 2.59 ± 1.91 ） mmoL/L, P 〈 0.05 ], SES [ （58.60 ±3.96） ng/mL vs （48.31±2.89） ng/mL, P 〈0.05 ] and hs-CRP [ （3.92 ±0.40） μg/mL vs （2.97 ±0.42） μg/mL, P 〈 0. 05 ] were reduced significantly after 6 months statins therapy. The serum level of HDL-C somewhat increased [ （ 0.90 ±0.23 ） mmol/L vs （ 1.01 ± 0.18 ） mmol/L ,P 〉 0.05 ]. Conclusion ： Statins therapy can significantly reduce the serum levels of the low grade inflammatory response factors hs-CRP and SES in patients with SCF.