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二尖瓣置换术后肝素诱导性血小板减少症的诊治体会 被引量:4

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摘要 肝素诱导性血小板减少症(heparin induced thrombocytopenia,HIT)是临床使用肝素治疗的不良反应之一,由抗血小板4因子-肝素复合物(PF4-H)抗体所介导的高血栓风险性疾病[1,2]。约占所有接受肝素患者的0.5%~5.0%,HIT相关性病死率高达5%~10%[2]。对于HIT患者,一方面血小板计数较低,出血风险较高;另一方面处于高凝高血栓风险状态,需要积极抗凝,预防血栓形成[3],这给临床医生带来极大诊疗困惑。现将我院诊治HIT1例报道如下。
出处 《内科急危重症杂志》 2014年第5期349-350,共2页 Journal of Critical Care In Internal Medicine
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参考文献5

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  • 2Watson H, Davidsou S, Keeling D, et al. Guidelines on the diagnosis and management of heparin-induced thrombocytopenia : Second edition [ J]. British journal of haematology,2012,159(5 ) :528-540.
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二级参考文献7

  • 1Kelton J G,Arnold D M,Bates S M. Nonheparin anticoagulants for heparin-induced thrombocytopenia[J].{H}The New England Journal of Medicine,2013,(08):737-744.
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共引文献6

同被引文献63

  • 1张庆祥,李宗虓,李秀勇,靖文斌.心脏术后肝素诱导血小板减少二例[J].中国心血管病研究,2009,7(10):766-767. 被引量:1
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  • 10Perrin J,Barraud D,Toussaint-Hacquard M,et al.Rapid onset heparin-induced thrombocytopenia (HIT) without history of heparin exposure:A new case of so-called ‘spontaneous' HIT[J].Thromb Haemost,2012,107 (4):795-797.

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