济宁市某校2012级大学新生乙型肝炎病毒感染调查

Analysis of HBV infection in 2012-grade freshmen of a college in Jining

目的了解山东省济宁市某校2012级大学新生乙型肝炎病毒(HBV)感染情况,为制定预防措施提供依据。方法对2012年3 605名新生采用酶联免疫法(ELISA)检测乙型肝炎病毒标志物(HBVM),赖氏法测定丙氨酸氨基转移酶(ALT)。结果济宁市某校新生HBVM阳性率为25.52%,城市、乡村学生HBVM阳性检出率分别为20.07%、28.96%,城市、乡村学生HBVM阳性率差异有统计学意义(χ2=1.12,P<0.05);男、女生HBVM阳性率差异亦有统计学意义(χ2=11.32,P<0.05);HBVM有16种组合模式,HBsAg阳性率为4.77%,其中城市学生为4.66%、乡村学生为4.84%,城乡学生差异有统计学意义(χ2=21.46,P<0.05);单纯HBsAb阳性占总检人数的14.98%。结论济宁市某校新生HBV感染状况不容忽视,应加强学生乙型肝炎疫苗的接种,对HBV易感者应及时接种并加强监测,必要时复种或加强接种。

Objective To understand HBV infection in 2012-grade freshmen of a college in Jining, to provide basis for formulating preventive measures. Methods HBVM and ALT of 3 605 freshmen of 2012-grade were detected with enzyme-linked immunosorbent assay（ELISA） and Reite＇s method. Results The positive rate of HBVM was 25.52%, and20.07% of the students from cities, 28.96% of the rural students with significant difference in positive rate of HBVM（χ^2=1.12,P0.05）. There was statistical difference in the positive rate between the male and female（χ^2=11.32,P0.05）. HBVM was of 16 kinds of patterns. The positive rate of HBsAg was 4.77%, including 4.66% of the students from cities, and 4.84%of the rural students, without significant difference between the urban and rural students（χ^2=21.46,P0.05）. 14.98% students had HBsAb only out of the examined students totally. Conclusions The infection of HBV in the freshmen can＇t be ignored. Preventive inoculation of hepatitis B vaccine should be reinforced. Students susceptible to HBV should be timely vaccinated and surveyed. Revaccination and booster inoculation should be carried out if necessary.