扶正化痰方联合GP方案治疗中晚期非小细胞肺癌的临床疗效观察

Clinical Observation on Fuzhenghuatan Herbs Combined with GP Chemotherapy in Treating Non-small Cell Lung Cancer

目的:观察扶正化痰方联合GP方案治疗中晚期非小细胞肺癌的临床疗效。方法:60例中晚期非小细胞肺癌随机分为2组,对照组(单纯化疗组)、治疗组(化疗+扶正化痰方组)各30例,治疗2个月后,观察2组疲劳程度、中医证候、体力状况、化疗不良反应等变化情况。结果:同对照组相比,治疗组能够明显降低患者的FSI总得分(P<0.05),在咳嗽、血痰、发热、胸痛、短气、乏力等中医证候的缓解及改善方面明显优于对照组(P<0.05),KPS评分治疗组明显高于对照组(P<0.05),另外,治疗组在减轻白细胞、血小板下降、恶心、呕吐以及避免神经毒性等化疗不良反应方面也具有明显优势(P<0.05)。结论:扶正化痰方对于中晚期非小细胞肺癌具有缓解患者疲劳症状、改善中医证候、提高生活质量及减轻化疗不良反应的作用。

Objective：To observe the clinical efficacy of Fuzhenghuatan formula combined with GP chemotherapy regimens in treating advanced non-small cell lung cancer. Methods：Sixty patients with advanced non-small cell lung cancer were randomly divided into two groups,the control group （ chemotherapy group, n = 30） and the treatment group （ chemotherapy ＋ FuZhengHuaTan herbs group, n = 30）. After the treatment of two months, the changes of indices including fatigues,TCM syndromes, physical conditions and chemotherapy side effects were observed. Results ： Compared with the control group, the treatment with Fuzhenghuatan herbs and chemotherapy could significantly reduce the total FSI score （P 〈 0. 05 ）, and TCM syndromes such as cough, bloody sputum, fever, chest pain, short breath, fatigue were better alleviated （ P 〈 0. 05）, and KPS score in the treatment group was significantly higher （ P 〈 0. 05 ） ; in addition, the treatment group also had obvious advantages in reducing white blood cells, platelets, nausea, vomiting, and chemotherapy neurotoxicity （P 〈 0. 05 ）. Conclusion ： Fuzhenghuatan herbs treating advanced non-small cell lung cancer patients can relieve fatigue and improve TCM syndromes, enhance quality of life and reduce the side effects of chemotherapy.