健脾调肝汤治疗晚期原发性肝癌对生活质量的影响

Impact of Jianpi Tiaogan Tang on Life Quality of Patients with Terminal Primary Liver Cancer

目的:观察健脾调肝汤治疗晚期原发性肝癌对生活质量的影响。方法:将60例患者随机分成治疗组与对照组各30例,2组患者均采用相同的西药(保肝、降酯、止痛等)治疗;治疗组同时加用健脾调肝汤治疗。2组均治疗1个月为1个疗程,2个疗程后评价疗效。观察2组中医证候变化、生活质量、体重变化、肝功能变化及不良反应。结果:2组中医临床证候变化比较,治疗组与对照组总改善率分别83.3%与60.0%(P<0.05);2组治疗后生活质量及体重变化比较,生活质量、体重治疗组高于对照组(P<0.05);2组治疗后肝功能变化比较,2组治疗后肝功能3项指标(ALT、AST、TBIL)较治疗前均有明显改善(P<0.05),其中ALT、AST水平治疗组较对照组改善更明显(P<0.05)。不良反应2组未见明显发生。结论:健脾调肝汤治疗晚期原发性肝癌可改善临床症状,减轻肝损害及不良反应,提高生活质量、延长生存期。

Objective ：To observe impact of Jianpi Tiaogan Tang on the life quality of patients with terminal primary liver cancer. Methods：Sixty patients were randomized to receive western medicine treatment （protecting liver, lipid lowering, pain relief, etc. ） , the treat- ment group took Jianpi Tiaogan Tang on top of western medicine treatment. After 2 treatment courses （ 1 month/course）, efficacy were evaluated. TCM syndrome, life quality, weight changes, liver function changes and adverse reaction were observed. Results：In terms of TCM syndrome changes, the total improvement rate of treatment group and control group were 83.3% and 60.0% respectively （P 〈0. 05 ） ; after treatment, the treatment group was significantly better than control group in terms of life quality, weight stabilization （ P 〈 0. 05 ） ; in terms of liver function, after treatment both groups showed significantly improved ALT,AST,TBil （ P 〈 0.05 ）. Treatment group had even better ALT, ASL levels compared to control group （ P 〈 0.05 ）. No adverse reaction was observed in both groups. Conclusion： Jianpi Tiaogan Tang can alleviate clinical symptoms of terminal primary liver cancer, reducing liver damage and adverse reaction, improve quality of life and prolong lifetime.