摘要
目的:研究巴西莓解酒防醉及对急性酒精性肝损伤的影响。方法:急性酒精中毒实验:小鼠按0.15 mL/10 g灌胃50%乙醇,建立急性酒精中毒动物模型,观察小鼠活动状况,醉酒潜伏期,醒酒时间。急性酒精性肝损伤实验:小鼠按0.12 mL/10 g灌胃50%乙醇,建立小鼠急性酒精性肝损伤模型,观察巴西莓对小鼠肝细胞膜通透性,肝脏脂质过氧化反应等的影响。结果:巴西莓可以延长醉酒潜伏期(P<0.05),缩短醉酒动物睡眠时间,且可降低血清ALT、AST(P<0.01),升高肝脏GSH(P<0.05)、SOD水平,降低肝脏MDA、TG含量(P<0.05),结论:巴西莓具有解酒防醉作用,且对酒精性肝损伤具有一定的保护作用。
Objective: To study the effects of Acai ( Euterpe Oleraceae Mart. ) on acute alcohol toxication and protective effect on acute alcohol liver injury in mice. Methods:Acute alcohol toxication animal model was established by alcohol gavaged (50% at 15 mL/kg). The acute liver injury animal model was established by alcohol gavaged (50% at 12 mL/kg). The serum levels of ALT,AST and the content of MDA,TG, the activity of GSH,SOD in liver of the mice were measured. Resuits:Acai can shorten the recovery time of tightening reflex compared with the model groups (P 〈 0. 05 ). The groups of Acai significantly reduced the levels of serum ALT, AST( P 〈 0. 01 ) which were induced by ethanol, and the content of MDA, TG ( P 〈 0. 05 ), the activity of GSH in liver were significantly different compared with those of the model groups ( P 〈 0. 05 ). Conclusion: Acai has effect of relieving alcohol toxicity and a protective effect on acute alcohol liver injury in mice and its mechanism may relate to the capacity of anti-oxidant.
出处
《世界中医药》
CAS
2014年第10期1334-1337,共4页
World Chinese Medicine
关键词
巴西莓
酒精中毒
肝损伤
抗氧化
Acai
Ethanol
Toxication
Liver injury
Anti-oxidant