巴西莓对急性酒精中毒小鼠的解酒及保肝作用研究

The Detoxication and Protective Effect of Acai Against Acute Alcohol Toxication and Acute Alcohol Liver Injury in Mice

目的:研究巴西莓解酒防醉及对急性酒精性肝损伤的影响。方法:急性酒精中毒实验:小鼠按0.15 mL/10 g灌胃50%乙醇,建立急性酒精中毒动物模型,观察小鼠活动状况,醉酒潜伏期,醒酒时间。急性酒精性肝损伤实验:小鼠按0.12 mL/10 g灌胃50%乙醇,建立小鼠急性酒精性肝损伤模型,观察巴西莓对小鼠肝细胞膜通透性,肝脏脂质过氧化反应等的影响。结果:巴西莓可以延长醉酒潜伏期(P<0.05),缩短醉酒动物睡眠时间,且可降低血清ALT、AST(P<0.01),升高肝脏GSH(P<0.05)、SOD水平,降低肝脏MDA、TG含量(P<0.05),结论:巴西莓具有解酒防醉作用,且对酒精性肝损伤具有一定的保护作用。

Objective： To study the effects of Acai （ Euterpe Oleraceae Mart. ） on acute alcohol toxication and protective effect on acute alcohol liver injury in mice. Methods：Acute alcohol toxication animal model was established by alcohol gavaged （50% at 15 mL/kg）. The acute liver injury animal model was established by alcohol gavaged （50% at 12 mL/kg）. The serum levels of ALT,AST and the content of MDA,TG, the activity of GSH,SOD in liver of the mice were measured. Resuits：Acai can shorten the recovery time of tightening reflex compared with the model groups （P 〈 0. 05 ）. The groups of Acai significantly reduced the levels of serum ALT, AST（ P 〈 0. 01 ） which were induced by ethanol, and the content of MDA, TG （ P 〈 0. 05 ）, the activity of GSH in liver were significantly different compared with those of the model groups （ P 〈 0. 05 ）. Conclusion： Acai has effect of relieving alcohol toxicity and a protective effect on acute alcohol liver injury in mice and its mechanism may relate to the capacity of anti-oxidant.