药物联合干预H型高血压临床疗效的研究

A study of effect of combined drug intervention on patients with H-type hypertension

目的通过观察非洛地平、卡托普利、叶酸及B族维生素联合干预H型高血压患者血压、颈动脉内膜中层厚度(CAIMT)及血清同型半胱氨酸(Hcy)水平变化,探讨药物联合干预H型高血压的临床疗效。方法对86例H型高血压患者实施非洛地平、卡托普利、叶酸及B族维生素联合干预8周,对比分析干预前后血压、CAIMT及血清Hcy水平变化。结果观察组干预前收缩压(SBP)、舒张压(DBP)、CAIMT及血清Hcy水平[(168.9±10.4)mm Hg,(92.5±11.3)mm Hg,(24.7±5.3)μmol/L,0.98±0.19]均显著高于对照组[(123.5±6.6)mm Hg,(71.8±7.9)mm Hg,(9.8±2.7)μmol/L,0.57±0.14)(P<0.01)],干预后SBP、DBP、CAIMT及血清Hcy水平[(130.2±8.9)mm Hg,(78.7±8.6)mm Hg,(10.9±4.2)μmol/L,0.76±0.13]均显著低于干预前(P<0.01)。药物联合干预H型高血压患者的总有效率为94.2%(81/86)。结论非洛地平、卡托普利、叶酸及B族维生素联合干预H型高血压患者,可显著改善血压、颈动脉粥样硬化及血液Hcy水平,临床疗效显著。

Objective By observing the change of blood pressure,CAIMT and Hcy levels in patients with H-type hyperten-sion who were treated with combined drugs intervention treatment（felodipine,captopril,folic acid and vitamin B）,to investigate the clinical efficiency of combined drug intervention on patients with H-type hypertension. Methods Eighty-six patients with H-type hypertension were given the combined drugs intervention treatment（felodipine,captopril,folic acid and vitamin B）for 8 weeks,and thus the changes of blood pressure,CAIMT and serum Hcy levels before and after intervention were comparatively an-alyzed. Results Before intervention,SBP,DBP,CAIMT and serum Hcy levels of observation group,[（168. 9 ± 10. 4）mm Hg （1 mm Hg = 0. 133 kPa）,（92. 5 ± 11. 3）mm Hg,（24. 7 ± 5. 3）μmol/ L,0. 98 ± 0. 19],were significantly higher than those of control group which were[（123. 5 ± 6. 6）mm Hg,（71. 8 ± 7. 9）mm Hg,（9. 8 ± 2. 7）μmol/ L,0. 57 ± 0. 14],P 〈 0. 01;and SBP,DBP,CAIMT and serum Hcy levels of observation group after intervention[（130. 2 ± 8. 9）mm Hg,（78. 7 ± 8. 6）mm Hg, （10. 9 ± 4. 2）μmol/ L,0. 76 ± 0. 13]were significantly lower than those before intervention（P 〈 0. 01）. The total effictive rate of treatment was 94. 2%（81 / 86）. Conclusion The combined drugs intervention（felodipine,captopril,folic acid and vitamin B） in the treatment of patients with H-type hypertension can significantly and effectively improve the blood pressure,carotid artery atherosclerosis and Hcy levels.