摘要
目的探讨Aurora-A基因在脑胶质瘤中的表达情况,以及在胶质瘤发生、进展及预后中的生物学意义。方法选取2011年3月至2013年4月在郑州大学第五附属医院神经外科行手术治疗的脑胶质瘤患者63例,利用SP法进行免疫组化检测Aurora-A基因蛋白表达情况,并分析Aurora-A表达与脑胶质瘤患者临床病理之间的关系。结果 AuroraA在不同病理级别脑胶质瘤中均有阳性表达,随着病理级别增加,阳性表达率逐渐增加,并且不同病理级别表达阳性率比较差异有统计学意义(P<0.05);Aurora-A阳性表达与不同病理级别、肿瘤复发、生存时间相关(P<0.05),胶质瘤病理级别越高、术后发生复发、生存期<2年的患者,Aurora-A阳性表达越高。结论 Aurora-A在脑胶质瘤的发生、进展中发挥了重要作用,对于判定脑胶质病理级别、进展程度和预后具有重要意义,可能为脑胶质瘤基因靶向治疗提供新的靶点。
Objective To investigate the expression of Aurora-A in human gliomas,and its biological significance in progres-sion and prognosis. Methods Sixty-three patients with gliomas,who were treated by surgery in neurosurgery,were selected at the fifth affiliated hospital of Zhengzhou university from March 2011 to April 2013. Aurora-A gene expressions were detected by SP method for immunohistochemical,and the relationships between the expression of Aurora-A and the clinicopathology of gliomas were analyzed. Results Aurora-A genes were expressed in different pathological grade gliomas. With the increase of the patho-logical level,the positive rate was gradually increased,and the level of expressions was different in different pathological,the differences were statistically significant（P 〈 0. 05）. The expression of Aurora-A were associated with different pathological lev-els,tumor recurrence and survival time（P 〈 0. 05）. With the higher level of pathological,postoperative recurrence and survival time 〈 2 years,the expressions of Aurora-A were higher. Conclusion Aurora-A plays an important role in the incidence and progress of gliomas. It has an important significance for the determination of pathological grade,progression and prognosis. It might provide new targets for gene targeting therapy of glioma.
出处
《临床医学》
CAS
2014年第11期15-17,F0003,共4页
Clinical Medicine
