地诺前列酮栓用于晚期妊娠引产的效果观察

Observation of the Curative Effect of Dinoprostone Suppositories in Late Pregnancy Induction

目的:探讨地诺前列酮栓用于妊娠晚期引产的效果极其安全性。方法:妊娠晚期患者360例随机分为观察组和对照组各180例。对照组采用缩宫素引产,观察组采用地诺前列酮栓引产。比较两组患者用药前后的宫颈Bishop评分、宫颈成熟率、临床效果、引产成功率、临产时间、分娩方式、新生儿结局及不良反应情况差异。结果:用药后两组Bishop评分均较前显著增加(P<0.05),且观察组评分更优于对照组(P<0.05)。观察组的宫颈成熟率、引产成功率、临产时间、阴道分娩率等各方面均显著优于对照组(P<0.05)。两组临床效果比较,观察组的显效率(45%)、总有效率(95%)均显著高于对照组(P<0.05)。观察组产后出血明显少于对照组(P<0.05),两组宫内窘迫、宫缩过强、新生儿Apgar评分等比较,差异无统计学意义(P>0.05)。结论:地诺前列酮栓用于妊娠晚期引产,能显著的提高宫颈成熟、引产成功率等指标,节省临产时间,减少产后出血,效果优于催产素。

Objective：Discuss the clinical effect and safety of dinoprostone being used in late pregnancy patients. Methods：Three hundred and sixty cases of late pregnant women were randomly divided into observation group and control group with 180 cases in each. The control group waere given oxytocin, the observation group were given dinoprostone supposi- tories to induced labor. The differences of cervical Bishop score before and after treatment, cervical ripening rate, clinical effect, the successful rate of induced labor, labortime, mode of delivery, neonatal outcome and adverse drug reaction of the two groups were compared. Results： After treatment, the Bishop score of two groups was significantly higher than non-treat- ment （P 〈 O. 05）, and the score of observation group was higher than control group （P 〈 0.05）. The observation group in cer- vical ripening rate, induction of labor the success rate, labor time, the rate of vaginal delivery were significantly better than the control group and the differences were statistically significant （P 〈 O. 05）. To evaluate the clinical effect of the two groups after the treatment, the observation group in significant efficiency （45%）, and the total efficiency （95%） was significantly higher than that of the control group （35.56% ,88.89% ） ,the differences were statistically significant in the assessment （P 〈 0. 05 ）. There were no statistically significant between the difference of the two groups in the intrauterine distress, metryperci： nesia, neonatal Apgar score （P 〉0. 05 ）. Conclusion： Dinoprostone suppositories in late pregnancy induced labor patients, not only can improve ripening, the success rate of induced labor and other indicators, save labor time, but also can reduce the sympton such as intrauterine distress, metrypereinesia, postpartum bleeding and other symptoms. The clinical efficacy was better than oxytocin.