怀山药多糖对大鼠胃溃疡的疗效及胃组织碱性成纤维细胞生长因子水平的影响

The effect of dioscorea opposita polysaccharide in the treatment of rats with gastric ulcer and its influence on the level of bFGF in gastric ulcer tissue

[目的]观察怀山药多糖对胃溃疡大鼠的治疗作用,研究怀山药多糖对胃溃疡大鼠胃组织碱性成纤维细胞生长因子(bFGF)水平的影响。[方法]将50只大鼠随机分为5组,分别为空白组、模型组、怀山药多糖组、替普瑞酮组和怀山药多糖+替普瑞酮组。观察并比较各组胃溃疡的愈合情况,取胃组织匀浆检测并比较bFGF水平。[结果]怀山药多糖组的溃疡指数显著低于模型组(P<0.01);怀山药多糖组的胃组织bFGF水平显著高于空白组(P<0.01)和模型组(P<0.05)。[结论]怀山药多糖具有良好的胃黏膜保护作用,其机制可能与上调胃溃疡大鼠胃组织bFGF水平有关。

[Objective]To observe therapeutic effect of Dioscorea opposita polysaccharide on gastric ulcer by glacial acetic acid in rats and effects of Dioscorea opposita polysaccharide on expression of bFGF in stomach tissue. [-Methods]Fifty rats were randomized into five groups. The efficacy of dioscorea opposite polysaccharide on gastric ulcer was observed. The expression of bFGF in gastric tissue was measured. I-Re- suits]The ulcer index of Dioscorea opposita polysaccharide group was obviously reduced compared with model group（P〈0.01）. The level of bFGF of Dioscorea opposita polysaccharide group was significantly higher than that of model group（P〈0. 05）or normal group（P〈0. 0l）. [Conclusion]Dioscorea opposita pol- ysaccharide has protective effects for gastric mucosa. The mechanism of protection may be related to pro- moting synthesis of bFGF.