146例HIV感染者/病人CD4^+T淋巴细胞计数变化情况分析

Changes of CD4^+T lymphocytes count in 146 cases infected with HIV

目的分析146例HIV/AIDS外周血CD4+T淋巴细胞的变化,为艾滋病防治工作提供科学依据。方法采用流式细胞术检测HIV/AIDS的外周血CD4+T淋巴细胞数并统计分析其特征。结果 146例HIV/AIDS中,初次检测的CD4+T淋巴细胞平均数为(346.40±182.14)个/μL;其中,CD4+T淋巴细胞<200个/μL的有40人,占27.4%;200~350个/μL的有43人,占29.5%;不同性别、年龄CD4+T淋巴细胞计数比较差异无统计学意义。未接受抗病毒治疗的艾滋病患者,在不同免疫状态的各组之间,CD4+T淋巴细胞绝对值在不同范围内的下降数有统计学差异(F=20.505,P<0.05);接受了抗病毒治疗的艾滋病患者,CD4+T淋巴细胞普遍可以回升,表明抗病毒治疗是有效的。结论 146例HIV/AIDS的CD4+T淋巴细胞免疫水平普遍偏低,初次检测中有27.4%新发现感染者已进入艾滋病期,对HIV感染者进行定期检测T淋巴细胞,对制定预防控制措施、监测病情的进展和制定治疗方案均具有重要的临床意义。

Objective To investigate changes of CD4 ＋ T lymphocyte count in peripheral blood of 146 HIV/AIDS patients so as to provide scientific basis for prevention and control of AIDS. Methods The number of CD4＋ T lymphocytes in peripheral blood of HIV/AIDS cases from 2009 to 2010 were counted by flow cytometry and statistically analyzed. Results Among 146 HIV/AIDS cases, the average number of first CD4＋T lymphocytes count were （346.40± 182.14） cells/μL and the CD4＋T cell counts in 40 cases （27.4%） were lower than 200/μL, and the CD4＋T cell counts of 29.5% （43 cases） of them ranged between 200-350 cells/uL . No significant differences in counts of CD4＋T of lymphocytes were noticed among the cases in different gender and age groups. There was statistical difference in reduction of CD4＋T of lymphocyte absolute value among different immune status of cases infected with HIV without receiving antiviral therapy（F= 20.505, P〈0.05）, while the count of CD4 ＋T of lymphocyte in those received antiretroviral therapy were generally increased indicating that antiviral therapy was effective. Conclusions The immune level of CD4 ＋T lymphocytes in 146 HIV/AIDS cases was low and 27.4% of them developed to AIDS phase, thus regular detection of CD4＋T lymphocyte level is of great importance for making preventive, monitoring and treatment measures.