广州市婴儿血清25-羟维生素D测定结果分析

Detection of serum 25-hydroxyl vitamin D levels in babies in two hospitals of Guangzhou city

目的了解广州市婴儿25-羟维生素D[25-（0H）D]水平，为佝偻病防治提供依据。方法对在儿童保健门诊进行常规体检的416例0-1岁婴儿常规采用酶联免疫法检测血清25-（OH）D水平。结果广州市416例婴儿25-（OH）D的测定平均值为（82．64～21．28）nm01]L，25-（OH）D缺乏和不足的婴儿为158例，占37．98％；25-（0H）D水平充足（合适水平）的为258例，占62．02％；男婴和女婴血清25-（0H）D水平（P=0．320）、维生素D缺乏和不足的患病率差异（P=0．868）均无统计学意义，6个月前婴儿的血清25-（OH）D水平较7～12月龄组高；婴儿血清25-（OH）D水平季节差别明显（辟O．000），夏季最高，冬季最低；4个月以内婴儿25-（OH）D水平纯母乳喂养组〈混合喂养组〈人工喂养组。结论广州市0-1岁婴儿25-（OH）D平均水平处于正常低值，25-（OH）D缺乏和不足的发病率高，应从围生期开始进行管理。

Objective To investigate 25-hydroxyl vitamin D level in serum of babies in two hospitals of Guangzhou and provide basis for the prevention and control of rickets. Methods ELISA was used to detect serum levels of 25-hydroxyvitamin D in 416 babies in two hospitals of Guangzhou . Results The mean value of 25-hydroxyvitamin D was （82.64±21.28） nmol/L and the 25-hydroxyvitamin D levels in 158 babies were deficient or insufficient,accounted for 37.98% and that in 258 babies were sufficient accounted for 62.02%. There were not statistically significant differences in serum 25-hydroxyvitamin D levels（P=-0.320） and vitD deficiency prevalence（P=0.868） between males and females （ P〉 0.05） , The 25-hydroxy vitamin D level was much higher in 0-6 months babies than that of 7-12 months babies exhibited statistically significant difference in different seasons （P=-0.000）,being highest in summer and lowest in winter; The 25-hydroxyvitamin D levels were exclusive in the deseending order of breasffeeding 〈 mixed feeding group 〈 artificial feeding group. Conclusion The levels of 25-hydroxyvitamin D in serum of babies in Guangzhou city are at lower limit of normal range and the intervention on the 25-hydroxyvitamin D levels in babies should initiate from the perinatal period.