无表面活性剂快速沉淀法制备盐酸吡格列酮微粉

Preparation of Micro-scale Particulates of Pioglitazone Hydrochloride by Rapid Precipitation without Surfactants

本研究在不加入表面活性剂条件下采用快速沉淀法制备盐酸吡格列微粉,分别利用扫描电镜(SEM)、X射线衍射(XRD)、红外光谱分析(FT-IR)等分析方法对原药及产品的性质进行了表征。SEM分析表明,使用快速沉淀法制备的盐酸吡格列酮超微粉尺寸降低,粒度分布均匀,FT-IR、X RD分析表明,微粉化前后药物的化学结构并未发生改变,粒度明显减小,结晶度明显降低。

The microsized pioglitazone hydrochloride（PH） was prepared via the rapid precipitation proces without surfactant. The microsized pioglitazone hydrochloride and the raw drug were well characterized by scanning electron microscopy （SEM）, powder X-ray diffraction （XRD）, fourier transform infrared spectrometry （FT-IR）. The study indicated that after micronization, the particle size decreased, the range of particle size distribution became well through SEM. FT-IR and XRD analysis indicated the particle size decreased and ccrystallinity decreased during the process and no change in chemical group structure.