肝细胞癌患者血清中MMP-9、m-AST检测的临床意义

Clinical significance of serum MMP-9 and m-AST detection in hepatocellular carcinoma

目的探讨肝细胞癌患者检测基质金属蛋白酶-9(MMP-9)、天冬氨酸氨基转移酶线粒体同工酶(m-AST)的临床意义。方法对40例肝细胞癌(不同病情)患者(肝细胞癌组)与40例对照组血清中MMP-9、m-AST检测结果进行比较。结果肝细胞癌组与对照组血清中MMP-9、m-AST比较差异有统计学意义(P<0.05);肝细胞癌患者血清中MMP-9、m-AST与患者有无合并腹水、肿瘤大小、肿瘤数目、病理分化程度有关,其差异有统计学意义(P<0.05)。结论 MMP-9、m-AST与肝细胞癌密切相关,可能是肝细胞癌的诊断和治疗的重要线索,其浓度水平对肝细胞癌的病情变化具有重要的价值。

Objective To investigate the clinical significance of matrix metallo preteinases-9 （MMP-9） and mitochondrial aspartic transaminase （m-AST） detection in hepatocellular carcinoma. Methods Levels of serum MMP-9 and m-AST of 40 patients of hepatocellular carcinoma with different conditions （hepatocellular carcinoma group） and 40 control cases were compared. Results The differences of serum MMP-9 and m-AST between hepatocellular carcinoma group and control group had statistical significance （P〈0.05）. Levels of serum MMP-9 and m-AST of hepatocellular carcinoma cases were related with ascites, tumor quantity and size, differentiation grade, and the differences were statistically significant （P〈0.05）. Conclusion MMP-9 and m-AST have close relation with hepatocellular carcinoma, and they play important roles in diagnosis and treatment of hepatocellular carcinoma. Concentration levels of MMP-9 and m-AST have important value for change of hepatocellular carcinoma.