阿尔茨海默病的防治研究进展

Advances in prevention and treatment of Alzheimer's disease

阿尔茨海默病（Alzheimer’s disease,AD）是以进行性记忆和认知功能障碍为主要临床表现的神经系统退行性疾病。全球已有AD患者近3 500万,我国约有600万,已成为威胁老年人生命健康的主要疾病。目前临床上采用胆碱酯酶抑制剂、乙酰胆碱受体激动剂、谷氨酸受体拮抗剂和脑代谢激活剂等来治疗AD,但本质上是对症治疗,不能有效预防或延缓疾病进展。现将AD治疗领域的研究现状和进展进行综述。

Alzheimer＇s disease（ AD） is the most common form of dementia in individuals over the age of 65. According to the amyloid-beta（ Aβ） cascade hypothesis,Aβ plays a vital role in the development of AD and becomes a major therapeutic target. Tau-targeting therapy,mitochondria-targeting therapy and stem cell transplantation are also known intervention strategies. Because multifactors are involved in the disease pathogenesis and the pathogenesis varies at different stages of the disease,we proposed that different targets should be targeted at different stages of the disease for an effective disease-modifying treatment.