摘要
目的:检测冠心病患者外周血血管性血友病因子裂解酶(von Willebrand factor-cleaving protease,vWF-cp)的水平变化以及联合全球急性冠脉注册事件(Global Registry of Acute Coronary Events,GRACE)评分观察对冠心病危险分层的评估价值。方法:选取冠心病患者96例,其中稳定性心绞痛组(stable angina pectoris,SAP)47例,急性冠脉综合征组(acute coronary syndrome,ACS)49例;同时选取同期无血管病变的非冠心病患者49例作为对照组,采用GRACE系统进行评分及分层,同时利用Gensini评分系统评定冠状动脉狭窄程度,用酶联免疫吸附法(enzyme-linked immuno sorbent assay,ELISA)测定外周血vWF-cp的浓度。结果:对照组的vWF-CP水平明显高于ACS组(P=0.000),亦明显高于SAP组(P=0.000),ACS组与SAP组相比,差异有统计学意义(P=0.023);ACS组GRACE评分明显高于对照组(P=0.000),SAP组亦明显高于对照组(P=0.008),ACS组与SAP组相比,ACS组明显升高,差异有统计学意义(P=0.033);不同Gensini积分的冠心病患者的vWF-cp水平比较,差异无统计学意义(P>0.05)。冠心病患者Gensini积分等级与vWF-cp水平无明显相关性(r=0.060,P=0.616)(采用Spearman’s rho法)。GRACE评分等级与vWF-cp水平呈负相关(r=-0.672,P=0.000)(采用Spearman’s rho法)。结论:GRACE评分联合vWF-cp可以在临床上更准确、有效的预测冠心病患者的风险及预后。
Objective:To investigate the peripheral blood of von Willebrand factor-cleaving protease(vWF-cp)levels in patients with coronary heart disease(CHD)and its correlation with global registry of acute coronary events(GRACE)score then to assess the risk of CHD with the combination of them. Methods:Totally 145 patients who underwent coronary angiography were selected as research subjects. They were divided into three groups by coronary angiography:49 patients with non-coronary heart disease as control group;47 patients with stable angina(SAP)as SAP group;49 patients with acute coronary syndrome(ACS)as ACS group. All patients were scored by GRACE system and then layered. Meanwhile,degree of coronary artery stenosis was assessed by Gensini scoring system and vWF-cp level was measured by ELISA. Results:vWF-cp levels in control group were strikingly higher than those in ACS group(P=0.000)and also higher than those in SAP group(P=0.000);vWF-cp levels in ACS group were obviously decreased compared with those in SAP group(P=0.023). GRACE scores in ACS and SAP groups were increased compared with those in control group(P=0.000)(P=0.008);GRACE score in ACS group was increased compared with that in SAP group(P=0.033). There was no significant difference in vWF-cp level among CHD patients with different Gensini scores(r=0.060,P=0.616),but GRACE score was negatively correlated with vWF-cp levels(r=-0.672,P=0.000). Conclusion:Combination of GRACE score and vWF-cp levels could predict risk and prognosis in patients with CHD accurately and efficiently.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2014年第9期1325-1328,共4页
Journal of Chongqing Medical University
基金
湖南省科技厅重点项目资助项目(编号:2009SK2010)
关键词
GRACE评分
血管性血友病因子裂解酶
冠心病
危险分层
Gensini积分
score of global registry of acute coronary events
von Willebrand factor-cleaving protease
coronary heart disease
risk layer
Gensini score