期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PTEN蛋白在大肠癌癌变过程中的表达及其意义 被引量：2

The expression and significance of PTEN in progression of colorectal cancer
下载PDF
导出
摘要 目的:研究PTEN蛋白在大肠癌癌变过程中的表达及其意义。方法:蛋白免疫印迹法检测107例大肠病变组织标本PTEN的表达情况,应用单因素方差分析及等级相关的秩和检验分析PTEN在大肠病变组织中的表达情况及其与临床病理特征间的关系。结果:PTEN蛋白在大肠癌癌变过程中,即在大肠正常组织、大肠增生性息肉、大肠腺瘤、大肠癌中表达阳性率呈递减趋势,差异有统计学意义(P<0.05)。大肠癌中PTEN蛋白与患者的肿瘤分化程度无关(P>0.05)。但是与临床分期相关(P<0.05)。结论:PTEN蛋白在大肠癌癌变过程中表达阳性率呈递减趋势,PTEN蛋白的低表达与大肠癌的发生和浸润转移相关。 Objective：To explore the expression and significance of PTEN in the progression of colorectal cancer.Methods：The expression of PTEN was examined in 107 specimens using Western Blot.The relationship between the expression of PTEN protein and clinicopathological factors was analyzed by K independent samples test and one-way ANOVA.Results：The positive rates for the expression of PTEN protein showed a gradual decrease respectively in normal colorectal tissue,colorectal adenoma and primary colorectal carcinoma.the difference was significant （P 〈 0.05）.There was also a significant difference in the positive rates of the PTEN expression in different Dukes＇stage（P〈 0.05）.No obvious correlation was found between expression of PTEN and pathological diagnosis （P 〉 0.05）.Conclusion：The positive rate for the expression of PTEN protein showed a gradual decrease in the progression of colorectal cancer,low-expression of PTEN protein is related with the development,invasion and metastasis of colorectal cancer.
作者 田华 宋于刚
机构地区 广东医学院附属厚街医院消化内科 南方医科大学南方医院消化疾病研究所
出处 《现代肿瘤医学》 CAS 2014年第11期2681-2683,共3页 Journal of Modern Oncology
关键词 大肠癌 PTEN 蛋白免疫印迹 colorectal cancer PTEN Western Blot
分类号 R735.3 [医药卫生—肿瘤]
  • 相关文献

参考文献15

  • 1Zhou XD,Lv NH. Epidemiology of colorectal cancer research[ J ]. Modem Digest Interv,2006,11 ( 3 ) : 149 - 151.
  • 2田华,孙嫣,肖法嫚,谢晓云,宋于刚.PTEN在大肠癌癌变过程中的表达及意义[J].胃肠病学和肝病学杂志,2009,18(6):542-545. 被引量：4
  • 3Steck PA, Pershouse MA ,Jasser SA, et al. Identification of a candi- date turnout suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers [ J ]. Nat Genet, 1997,15 (4) :356 -362.
  • 4Wang Y, Wang X,Zhang J, et al. MicroRNAs involved in the EG- FR/PTEN/AKT pathway in gliomas [ J ]. J Neurooncol, 2012,106 (2) :217 -224.
  • 5Ettl T, Baader K,Stiegler C ,et al. Loss of PTEN is associated with elevated EGF - R and HER2 expression and worse prognosis in salivary gland cancer[ J]. Br J Cancer,2012,106 (4) :719 - 726.
  • 6SoL, Fruman D A. PI3 K signal ling in B - and T - lymphocytes : new developments and therapeutic advances [ J]. Biochem J,2012,442 (3) :465 -481.
  • 7lta M, Chung JW, Hahm KB, el al. A case of Cuwden syndrome di- agnosed tom multiple gastric polyposis[ J]. World J Gastroenterol, 2012,18(8) :861 -864.
  • 8Zhou J, Roh JW, Bandyopadhyays, et al. Over expression of enhan- cer of zeste homolog2 ( EzH2 ) and focal adhesion kinase(FAK) in high grade endom etrialearci -noma [ J]. Gyneeol Oneol,2013, 128(2) :344 -348.
  • 9Villa - Maruzzi E. P'IN 12 controls PTEN and tile AKT signalling to FAK and HER2 in migrating ovarian cancer cells [ J ]. Mol Cell Bioehem,2013,375(1 -2) :151 - 157.
  • 10Ko HS, Lee H J, Kim SH, et al. Piceatannol suppresses breast cancer cell invasion throuh the inhibition of MMP - 9: involve- ment of PI3K/AKT and NF - KB pathways [ J ]. J Agric Food Chem,2012,60(16) :4083 -4089.

二级参考文献73

  • 1杨福文,胡俊波,杨传永.大肠良恶性肿瘤中PTEN的蛋白表达及其临床意义[J].临床外科杂志,2004,12(7):415-417. 被引量：8
  • 2王喜梅,刘逢吉,孙雷,郑仁恕.PTEN和survivin在宫颈腺癌中的表达及其与HPV16/18感染的关系[J].肿瘤,2006,26(9):847-850. 被引量：9
  • 3周晓东,吕农华.大肠癌的流行病学研究现状[J].现代消化及介入诊疗,2006,11(3):149-151. 被引量：72
  • 4Leminen A, Paavonen J, Forss M, et al. Adenocarcinoma of the uterine cervix. Cancer, 1990, 65 ( 1 ) :53-59.
  • 5Tavassoli FA, Hoefler H, Holland R, et al. Tumours of the uterine cervix//Tavassoli FA, Devilee P. World Health Organization classification of tumours. Pathology and genetics of the breast and female genital organs. Lyon : IARC Press, 2003:272-275.
  • 6Cullimore JE, Luesley DM, Rollason TP, et al. A case of glandular intraepithelial neoplasia involving the cervix and vagina. Gynecal Oncol, 1989,34(2) :249-252.
  • 7Gloor E, Hurlimann J. Cervical intraepithelial glandular neoplasia (adenocarcinoma in situ and glandular dysplasia). A correlative study of 23 cases with histologic grading, histochemical analysis of mucins, and immunohistocqehemical determination of the affinity for four lectins. Cancer, 1986,58 (6) : 1272-1280.
  • 8Kurian K, al-Nafussi A. Relation of cervical glandular intraepithelial neoplasia to microinvasive and invasive adenocarcinoma of the uterine cervix: a study of 121 cases. J Clin Pathol, 1999,52 (2): 112-117.
  • 9Fromowitz FB, Viola MV, Chao S, et al. Ras p21 expression in the progression of breast cancer. Hum Pathol, 1987,18 ( 12 ) : 1268- 1275.
  • 10Risinger JI, Hayes AK, Berchuck A, et al. PTEN/MMAC1 mutations in endometrial cancers. Cancer Res, 1997, 57 (21) : 4736-4738.

共引文献16

同被引文献27

  • 1张谷月,张志勇,王晔,吴晨鹏,张林,刘丽云,李华,云翔,沈福海.PTEN在结肠癌组织中的表达及其临床意义[J].中国老年学杂志,2014,34(12):3270-3271. 被引量：5
  • 2Bohn BA,Mina S,Krohn A,et al.Altered PTEN function caused by deletion or gene disruption is associated with poor prognosis in rectal but not in colon cancer[J].Hum Pathol,2013,44(8):1524-1533.
  • 3Yu M,Trobridge P,Wang Y,et al.Inactivation of TGF-beta signaling and loss of PTEN cooperate to induce colon cancer in vivo[J].Oncogene,2014,33(12):1538-1547.
  • 4Chandrasekaran S,Deng H,Fang Y.PTEN deletion potentiates invasion of colorectal cancer spheroidal cells through 3D Matrigel[J].Integr Biol(Camb),2015,7(3):324-334.
  • 5Ripple MJ,Parker SA,Trillo-Tinoco J,et al.Activation of c-Myc and Cyclin D1 by JCV T-Antigen and beta-catenin in colon cancer[J].PLoS One,2014,9(9):106257.
  • 6He X,Tan X,Wang X,et al.C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion[J].Tumour Biol,2014,35(12):12181-12188.
  • 7Martino-Echarri E,Henderson BR,Brocardo MG.Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase:a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy[J].Oncotarget,2014,5(20):9889-9900.
  • 8Fu X,Shi L,Zhang W,et al.Expression of Indian hedgehog is negatively correlated with APC gene mutation in colorectal tumors[J].Int J Clin Exp Med,2014,7(8):2150-2155.
  • 9Fer|ay J, Soerjomataram 1, Dikshit R, et al. Cancer incidence and mortality worldwide : Sources, methods and major patterns in GLOB- OCAN 2012[J]. lnt J Cancer,2015,136(5) :E359 -E386.
  • 10Kalyan A, Nimeiri H, Kulik L. Systemic therapy of hepatoeellular carcinoma: current and promising [ .I ]. Clin Liver Dis, 2015,19 (2) :421 -432.

引证文献2

二级引证文献2

现代肿瘤医学
2014年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部