喉鳞状细胞癌组织中MICA的表达及临床意义

Relationship between the major histocompatibility complex classⅠchain-related gene A expression and clinicopathologic features in laryngeal squamous carcinoma

目的:探讨主要组织相容性复合物Ⅰ类链相关基因A(MICA)在喉鳞状细胞癌(LSCC)组织中的表达及临床意义。方法:采用免疫组织化学、RT-PCR方法检测LSCC组织中MICA的表达情况,分析其与LSCC临床病理特征的关系。结果:MICA在LSCC组织中高表达,而正常组织中微弱表达或不表达,癌组织与正常组织中MICA的表达差异有统计学意义(P<0.01)。MICA在LSCC组织中的表达水平与肿瘤的临床分期和病理分级有密切关系,在早期、分化较好的LSCC组织中MICA表达水平较低,而在晚期、分化较差的LSCC组织中表达水平较高。结论:MICA可能参与了LSCC的侵袭和转移过程,有望成为LSCC的肿瘤标记物。

Objective：To investigate the expression of major histocompatibility complex classⅠchain-related gene A（MICA）in laryngeal squamous cell carcinoma（LSCC）,and its clinical significance.Method：Immunohistochemistry and RT-PCR were used to detect the expression of the MICA in LSCC and normal tissue samples.The relationship between the expression of MICA and the clinicopathologic features features werewas analyzed.Result：Compared to the expression of MICA in normal tissues samples,the expression of MICA in LSCC tissue was significantly increased（P〈0.01）.MICA expression level in carcinoma tissue was closely related to the tumor-differentiation degree and TNM staging.Conclusion：Our study suggests that MICA may play an important role in the invasion and metastasis of LSCC,and could be a potential tumor maker for LSCC.