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寡聚化α-突触核蛋白在不同年龄段食蟹猴消化道中的表达 被引量：3

Differential expressions of oligomer α-synuclein in digestive tract in different ages of cynomolgus monkeys
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摘要 目的研究寡聚化α-突触核蛋白(oligomer-α-synuclein,oligo-α-Syn)在不同年龄段食蟹猴消化道中的表达差异。方法 Western blotting和ELISA方法检测oligo-α-Syn在不同年龄段食蟹猴消化道中的表达。结果在老年食蟹猴的食管、胃底、十二指肠、空肠、回肠和结肠中,寡聚化α-Syn浓度较青年与中年猴显著增加,且差异有统计学意义(P<0.01)。结论食蟹猴消化道的各部位中α-Syn寡聚体表达具有增龄性变化。 Objective To explore the expressions of oligomer α-synuclein（ oligo-α-Syn） in digestive tract in different ages of cynomolgus monkeys. Methods Western blotting and ELISA was applied to measure the expressions of oligo-α-Syn in different ages of cynomolgus monkeys. Results The α-Syn oligomers increased significantly in the esophagus,stomach,duodenum,jejunum,ileum,colon of old monkeys compared with that of young and old monkey（ P 〈0.01）. Conclusion Oligo-α-Syn are the highest in digestive tract of old cynomolgus monkeys.
作者 李昕 杨巍巍 李旭冉 于顺
机构地区 首都医科大学宣武医院神经生物学研究室教育部神经变性病重点实验室 北京市老年病医疗研究中心分子诊断实验室
出处 《首都医科大学学报》 CAS 2014年第5期592-595,共4页 Journal of Capital Medical University
基金 国家重点基础研究发展计划(2011CB504101) 国家自然科学基金(81071014 81371200) 国家科技支撑计划课题(2012BAI10B03) 首都卫生发展科研专项课题(2011-4001-01) 北京市自然科学基金(7122035)~~
关键词 Α-突触核蛋白 寡聚化α-突触核蛋白 消化道 食蟹猴 α-synuclein（α-Syn） oligomer α-synuclein（oligo-α-Syn） digestive tract cynomolgus monkeys
分类号 R338 [医药卫生—人体生理学]
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参考文献15

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共引文献13

同被引文献29

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首都医科大学学报
2014年 第5期

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