替罗非班致急性重度血小板减少1例

Acute profound thrombocytopenia during tirofiban treatment:One case report

1病例资料 患者,男,48岁。1年前因急性心肌梗死于当地医院就诊,行冠状动脉（冠脉）造影检查,术中提示回旋支近段临界病变,未行介入治疗,术中使用普通肝素抗凝,住院期间曾使用低分子肝素,院外坚持服用拜阿司匹林、氯吡格雷、瑞舒伐他汀、β-受体阻滞剂,9个月后停服氯吡格雷,期间病情保持相对平稳,随访血常规及血生化检查无明显异常。

Tirofiban is a novel Glycoprotein（GP）Ⅱb/Ⅲa inhibitor that competitively inhibits the platelet fibrinogen receptor,which is frequently used in patients with acute coronary syndromes who underwent percutaneous coronary interventions（PCI）.We reported a case of acute profound thrombocytopenia due to tirofiban treatment in which overall platelet count dropped precipitously to 5×10^9/L within 24 hours.