频域光学相干断层扫描在早期糖尿病视网膜病变检测中的应用

Cirrus HD-OCT detection of macular retinal thickness in diabetic patients without diabetic retinopathy

目的：利用频域光学相干断层扫描（OCT）定性、定量检测并分析正常人群和眼底镜下无糖尿病视网膜病变的糖尿病患者的黄斑区视网膜的形态、厚度等改变,为糖尿病视网膜病变的早期发现及随访提供可靠的检测手段.方法：采用Cirrus HD-OCT的512×128扫描模式及5线高清扫描模式检测糖尿病患者双眼黄斑视网膜平均厚度、黄斑中心凹视网膜厚度及黄斑部9个分区的视网膜厚度,与正常对照组进行比较,并对结果行统计学分析.结果：糖尿病患者60例（120只眼）,根据糖尿病视网膜病变分期标准,眼底均表现为无糖尿病视网膜病变（NDR）.糖尿病NDR组与正常对照组相比,黄斑区视网膜厚度外环的鼻侧和颞侧与正常眼之间差异有统计学意义.其余各区的视网膜厚度与正常眼之间没有差异.结论：NDR组与正常对照组相比,黄斑区视网膜厚度外环的鼻侧和颞侧与正常眼之间有差异.这为在临床上早期发现糖尿病视网膜病变提供了客观依据,并便于随访观察.

Objective： To provide reliable means of detection for the early detection and follow-up of diabetic retinopathy by frequency domain optical coherence tomography （OCT） qualitative and quantitative detection and analysis of changes of macular shape and thickness in normal population and patients with diabetes without diabetic retinopathy. Methods： Cirrus HD-OCT 512 × 128 cube scan pattern and 5-wire HD scan mode were used to measure the macular retinal average thickness, foveal retinal thickness and the thickness of nine partitions of macular retinal, and the results were analyzed statistically. Results： Diabetic patients 60 cases （120 eyes）, according to the stage of diabetic retinopathy, all showed no diabetic retinopathy （NDR）. The difference between the nasal and temporal outer macular thickness of diabetes NDR group and the normal control group was statistically significant. There was no significant difference between the remaining subfields. Conclusion： There are significant differences between the nasal and temporal side of outer macular retinal thickness of NDR group and control group. It provides an objective basis for early clinical diabetic retinopathy detection and facilitates follow-up observation.