血浆BNP检测在慢性心力衰竭诊断及预后评估中的意义

Significance of plasma BNP for diagnosis and prognosis in chronic heart failure

目的探讨血浆BNP检测在慢性心衰诊断及预后评估中的临床意义。方法回顾性分析慢性心力衰竭患者100例的临床资料,分析BNP水平与心功能分级、左室射血分数、左室舒张末期内径的关系。并根据BNP水平分为>400pg/mL组和≤400pg/mL组,比较两组患者房颤、陈旧性心肌梗死以及死亡率。结果随着心功能分级的升高,BNP水平显著升高,LVEF水平显著下降,LVEDD显著增加(P<0.01)。BNP与心功能分级和LVEDD呈正相关(r=0.921,0.917,P<0.01),与LVEF呈负相关(r=-0.960,P<0.01)。BNP水平>400pg/mL的患者房颤、陈旧性心梗的发生率及死亡率更高(P<0.05或<0.01)。结论血浆BNP水平检测能够反映慢性心衰患者左心室功能,对患者诊断、预后评估均具有重要的临床意义。

Objective To discuss Significance of BNP for diagnosis and prognosis in chronic heart failure. Methods Selected 100 cases with chronic heart failure were retrospectively studied. Relationships between BNP and NYHA, LVEF, LVEDD were analyzed. All patients were divided into〉400pg/mL group and ≤ 400pg/mL group according to BNP levels, and AF, old myocardial infarction and mortality rates were compared. Results With the increase of cardiac function, BNP levels were significantly increased, LVEF significantly decreased, and LVEDD significantly increased（P 〈 0.01）. BNP showed a significant positive correlation with cardiac function and LVEDD （r=0.921,0.917,P 〈 0.01）, and showed a significant negative correlation with LVEF（r= -0.960, P 〈 0.01）. AF, old myocardial infarction and mortality rates in 〉 400pg/mL group were higher than ≤ 400pg/mL group（P 〈 0.05 or〈 0.01）. Conclusion Detection of plasma BNP levels reflects left ventricular function in patients with chronic heart failure, and has important clinical significance for diagnosis and prognosis.