摘要
目的比较18F-脱氧葡萄糖(18F-FDG)符合探测显像及99mTc-亚甲基二膦酸盐(99mTc-MDP)骨显像在肿瘤骨转移诊断及疗效评价中的价值。方法收集本院行18F-FDG符合探测显像及99mTc-MDP骨显像的骨转移患者42例,平均年龄(53.62±12.48)岁。其中未进行任何治疗患者18例,另11例治疗后多次(2~5次)行18F-FDG符合探测显像及99mTc-MDP全身骨显像。两种检查在1周内完成。比较两种方法在肿瘤骨转移诊断及疗效评价中的价值。结果 18F-FDG符合探测显像有36例明确诊断,99mTc-MDP骨显像有32例明确诊断,两种方法的诊断准确率差异无统计学意义(χ2=1.25,P=0.320)。18例未行治疗患者中,18F-FDG符合探测显像均明确诊断,99mTc-MDP骨显像有12例明确诊断,两种方法的诊断准确率差异有统计学意义(χ2=4.17,P<0.05)。治疗后疗效评价,符合探测显像复查结果与临床疗效评估结果有较强的正相关性(r=0.834,P<0.02)。结论 18F-FDG符合探测显像在初诊骨转移患者诊断及患者疗效评价中较99mTc-MDP骨显像有优势。
Objective To compare the value of 18F-fluorodeoxyglucose （18F-FDG） dual-head tomography with coincidence （DHTC） and 99mTc-methylenediphosphonate （99mTc-MDP） bone scintigraphy （BS） in diagnosis and therapeutic evaluation of bone metastases. Methods A total of 42 cases with cancer bone metastases, averagely aged （53.62±12.48） years old, were enrolled in this study. 18 cases did not receive any treatment, and 11 patients received inspection 2-5 times for assessment of therapeutic effects. 18F-FDG DHTC and 99mTc-MDP BS were performed within one week in all patients. The sensitivity, specificity and accuracy of 18F-FDG DHTC and 99mTc-MDP BS were compared. Results Of the 42 patients with bone metastases, 36 cases were correctly detected by 18F-FDG DHTC, and 32 were correctly detected by 99mTc-MDP BS. The difference of the sensitivity was not significant （χ2=1.25,P=0.320）. Among 18 patients who did not receive any treatment, all got correct diagnosis by 18F-FDG DHTC, and 12 were positive on 99mTc-MDP BS. The difference of the diagnostic accuracy was significant （χ2=4.17,P〈0.05）. The result of 18F-FDG DHTC was strongly correlated with the clinical therapeutic evaluation（r=0.834,P＆lt;0.02）. Conclusion 18F-FDG DHTC offers an advantage in diagnosis and therapeutic evaluation of bone metastases over 99mTc-MDP BS.
出处
《肿瘤影像学》
2014年第3期196-199,共4页
Oncoradiology
