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bFGF抑制自噬相关蛋白LC3保护大鼠急性脊髓损伤 被引量:3

Basic fibroblast growth factor protects rat model of spinal cord injury by inhibiting autophagy related protein LC3
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摘要 脊髓损伤( spinal cord injury, SCI)的治疗一直是神经损伤修复领域的医学难题,其致残率与致死率非常高。自噬( autophagy)是一种细胞通过溶酶体降解途径调控的细胞器和蛋白循环过程,其与衰老、免疫、细胞死亡和分化有关[1]。碱性成纤维生长因子( basic fibroblast growth factor,bFGF)具有促进血管生成、神经保护、轴突再生、组织修复等作用。故本文研究bFGF与细胞自噬相关蛋白LC3在脊髓损伤修复过程中的作用。
出处 《中国药理学通报》 CAS CSCD 北大核心 2014年第11期1625-1626,共2页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No 81200958) 宁波市自然科学基金资助项目(No 2013A610275)
关键词 自噬 碱性成纤维细胞生长因子 脊髓损伤 LC3 蛋白质印迹 免疫荧光染色 LC3 autophagy basic fibroblast growth factor spinal cordinjury LC3 Western blot immunofluorescence staining
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  • 1Meschini S, Condello M, Lista P, et al. Autophagy: molecular mechanisms and their implications for anticancer therapies [ J ]. Curt Cancer Drug Targets, 2011, 11(3) :357 -79.
  • 2Basso D M, Beattie M S, Bresnahan J C. A sensitive and reliable locomotor rating scale for open field testing in rats [ J ], J Neuro- trauma, 1995, 12 ( 1 ) : 1 - 21.
  • 3Moon Y J, Lee J Y, Oh M S, et al. Inhibition of inflammation and oxidative stress by Angelica dahuricae radix extract decreases ap- optotie cell death and improves functional recovery after spinal cord injury[ J]. J Neurosci Res, 2012, 90( 1 ) :243 - 56.
  • 4Tanabe F, Yone K, Kawabata N, et al. Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxie neuronal ceils [J]. Autophagy, 2011,7(12) :1462-71.

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  • 1丁永忠,孙群周,张建生.急性颅脑损伤后血清TNF-α,IL-1,IL-6,IL-8含量变化及其临床意义[J].中国临床神经外科杂志,2006,11(1):17-19. 被引量:56
  • 2Zhu M, Lu M, Li Q J, et al.Hyperbaric oxygen suppresses hypoxicischemic brain damage in newborn rats[J].J Child Neurol, 2015, 30(1):75-82.
  • 3Khaksari M, Aboutaleb N, Nasirinezhad F, et al.Apelin-13 protects the brain against isehemie reperfusion injury and eerebral edema in a transient model of focal cerebral ischemia[J].Joumal of Molecular Neuroseience, 2012, 48 ( 1 ) : 201-208.
  • 4Galanth C, Hus-Citharel A, Li B, et al.Apelin in the control of bpdy fluid homeostasis and cardiovascular funetions[J].Curr Pharm Des, 2012, 18 (6) : 789-798.
  • 5Bederson J B, Pitts L H, Tsuji M, et al.Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination[J].Stroke, 1986, 17 ( 3 ) : 472-476.
  • 6Kim J.Apelin-APJ signaling: a potential therapeutic target for pulmonary arterial hypertension[J].Mol cells, 2014, 37 ( 3 ) :196-201.
  • 7Galanth C, Hus-Citharel A, Li B, et al.Apelin in the control of body fluid homeostasis and cardiovascular funetions[J].Curr Pharm Des, 2012, 18 (6) : 789-798.
  • 8Cudnoch J A, Czarzasta K, Gomolka R, et al.The role of apelin in pathogenesis of cardiovascular diseases and metabolic disorder[J].Kardiol Pol, 2011, 69 ( Suppl 3 ) : 89-93.
  • 9Jiao H, Zhang Z, Ma Q, et al.Mechanism underlying the inhibitory effect of Apelinl3 on glucose deprivation induced autophagy in rat cardiomyocyte[J].Experimental and Therapeutic Medicine, 2013, 5 ( 3 ) : 797-802.
  • 10Cui R R, Mao D A, Yi L, et al.Apelin suppresses apoptosis of human vascular smooth muscle cells via APJ/PI3-K/Akt signaling pathways[J].Amino Acids, 2010, 39 ( 5 ) : 1193-1200.

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