肌酐正常患者中β2-微球蛋白与骨质疏松的相关分析

The correlation analysis between β2-microglobulin level and osteoporosis in patients with normal creatinine

目的探讨肌酐正常患者血清中β2-微球蛋白与骨质疏松的关系。方法选择2013年1月-2013年7月在中山大学附属第三医院住院患者364例肌酐正常患者,年龄15~84岁,平均年龄56.12岁。检测患者血清中β2-微球蛋白、肌酐及骨密度水平,并根据骨密度结果和世界卫生组织推荐的诊断标准将患者分为骨质疏松、骨量减少和骨量正常3组。比较3组间肌酐和血清中β2-微球蛋白水平,并将患者骨密度水平和血清中β2-微球蛋白水平行相关分析。结果 3组患者间肌酐水平无明显差异,骨质疏松组患者血清中β2-微球蛋白水平较骨量正常组患者血清中β2-微球蛋白升高,差异具有统计学意义（P〈0.05）。骨密度水平与血清中β2-微球蛋白水平呈负相关（P〈0.05）。结论在肌酐正常患者中血清中β2-微球蛋白与骨质疏松相关,β2-微球蛋白对骨质疏松的影响可能是独立于肾功能的。

Objective To investigate the relationship between serum β2-microglobulin level and osteoporosis in patients with normal creatinine.Methods Three hundred and sixty-four patients with normal creatinine,who were treated in the Third Affiliated Hospital of Sun Yat-sen University from January 2013 to July 2013,were selected.They were 15 to 84 years old,with an mean of 56.12 years old.The levels of creatinine and β2-microglobulin in serum and bone mineral density（BMD） of the patients were examined.The patients were divided into 3 groups：osteoporosis group,bone mass loss group,and normal bone mass group based on the results of BMD and the diagnostic criteria recommended by World Health Organization.The levels of creatinine andβ2-microglobulin in serum were compared among the 3 groups.The correlation between BMD and β2-microglobulin was analyzed.Results The creatinine levels among the 3 groups had no significant difference.β2-microglobulin level in osteoporosis group was higher than that in normal bone mass group,and the difference was statistically significant（P 0.05）.BMD was negatively correlated with serum β2-microglobulin level（P 0.05）.Conclusion β2-microglobulin was correlated with osteoporosis in patients with normal creatinine,and the impact of β2-microglobulin in osteoporosis may be independent of renal function.