老年男性糖尿病患者骨质疏松与动脉硬化的相关性研究

Correlation between atherosclerosis and osteoporosis in elderly male patients with type 2diabetes

目的探讨老年男性糖尿病人群骨质疏松与动脉硬化的相关性。方法测定226例老年男性糖尿病患者的股骨近端骨密度(BMD),将其分为骨质疏松组和非骨质疏松组,分别比较两组的一般情况,同时采用动脉硬化检测仪测定其踝肱指数(ABI)和脉搏波传导速度(PWV)。结果骨质疏松组患者的吸烟比例较非骨质疏松组高,差异有显著性(P<0.05)。骨质疏松组患者的ABI显著低于非骨质疏松组,PWV高于骨质疏松组,两组比较差异有显著性(P<0.05)。随BMD水平下降,所有患者的PWV水平升高,ABI降低,提示动脉硬化程度加重。结论老年男性糖尿病骨质疏松患者更易并发动脉粥样硬化病变,治疗和预防时应采取系统性的措施。

Objective To study the relationship between atherosclerosis and osteoporosis in elderly male patients with type 2diabetes.Methods Bone mineral density（BMD） of the proximal femurs in 226 elderly male patients with type 2 diabetes was measured.The patients were divided into osteoporosis group and non-osteoporosis group.The general status between the two groups was compared.PWV and ABI were measured using an atherosclerosis detector.Results Percentage of smoking patients was significantly more in osteoporosis group than in non-osteoporosis group（P 0.05）.ABI was significantly lower in osteoporosis patients than in non-osteoporosis patients（P 0.05）.PWV was significantly higher in non-osteoporosis patients than in osteoporosis patients（P 0.05）.With the decrease of BMD,PWV increased but ABI decreased in all patients,suggesting the severity of atherosclerosis.Conclusion Elderly male patients with type 2 diabetes and osteoporosis may be easier to combine with atherosclerosis.Systematic treatment an prevention should be applied.