鲑鱼降钙素影响骨质疏松患者血清胰岛素样生长因子、白介素6和肿瘤坏死因子α的临床观察

Clinical observation of the effect of miacalcic on the serum IGF-1,IL-6 and TNF-α in patients with osteoporosis

目的研究鲑鱼降钙素对骨质疏松患者骨密度和体内细胞因子的影响。方法将本院60例骨质疏松患者随机分成两组,对照组30例口服钙尔奇D 1片/天,观察组30例在对照组治疗方案基础上加用鲑鱼降钙素。治疗前后检测两组患者第2-4腰椎和股骨颈骨密度(Bone mineral density,BMD)、胰岛素样生长因子-1(Insulin-like growth factor-1,IGF-1)、血清白细胞介素6(Interleukin-6,IL-6)、肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)的变化,观察患者临床症状的改善。结果 (1)观察组第2-4腰椎和股骨颈BMD升高较对照组明显(P<0.05);(2)观察组患者IGF-1、IL-6以及TNF-α水平明显低于对照组(P<0.01);(3)观察组患者骨痛改善率高于对照组(P<0.05)。(4)无论治疗组还是对照组的BMD均与IGF-1呈正相关,与IL-6和TNF-α呈负相关。结论鲑鱼降钙素可有效提升骨质疏松患者腰椎和股骨颈BMD,并能够改善IGF-1、IL-6以及TNF-α水平,有效缓解疼痛。

Objective To evaluate the effect of miacalcic on bone mineral density（BMD） and cytokines in the osteoporotic patients.Methods Sixty patients with osteoporosis were equally randomly assigned into 2 groups.Patients in control group（30cases） received 600 mg Caltrate per day.Patients in observation group（30 cases） received miacalcic besides Caltrate.The BMD of L2-4 lumbar spine and the femoral neck,insulin-like growth factor-1（IGF-1）,interleukin-6（IL-6）,and tumor necrosis factor-α（TNF-α） were determined before and after the treatment.Clinical symptoms were observed.Results BMD of the L2-4 lumbar spine and the femoral neck were higher in observation group than in control group（P 0.05）.The serum levels of IGF-1,IL-6,and TNF-α were lower in observation group than in control group（P 0.01）.Pain was significantly relieved in the treatment group compared to control group（P 0.05）.BMD change was positively correlated to IGF-1 but negatively correlated to IL-6 and TNF-α in both groups.Conclusion Miacalcic is effective to improve BMD and to relieve pain in patients with osteoporosis.It can improve the levels of IGF-1,IL-6,and TNF-α.It can effectively relieve pain.