新疆不同民族舌体鳞状细胞癌HPV16、18表达率及其相关危险因素分析

Different Ethnic Groups in Xinjiang Squamous Cell Carcinoma of the Tongue Body HPV16,18 Expression Rate and Related Risk Factors Analysis

目的：检测新疆不同民族舌体鳞状细胞癌中HPV16、18表达率,并探讨HPV16、18感染的危险因素。方法：回顾性分析2004年6月~2013年6月本院明确诊断为舌鳞状细胞癌患者63例,利用PCR技术检测不同民族舌体鳞癌中HPV16、18总体及亚型感染率,并收集患者临床及详细病理资料,研究与HPV16、18感染的相关危险因素。结果：63例舌体鳞状细胞癌患者中,HPV16、18总体感染率为28.6%。HPV16感染率为23.8%;HPV18感染率为7.9%;HPV16及HPV18交叉感染2例,维吾尔族及汉族各1例。其中维吾尔族患者HPV16、18总体感染率为36.8%。哈萨克族患者HPV16、18总体感染率为10%。汉族HPV16、18总体感染率为29.4%。单因素分析显示：舌体鳞状细胞癌患者HPV感染与年龄、性别、民族、部位无统计学差异,而与吸烟和饮酒有统计学差异（P〈0.05）。Logistic多因素回归分析显示：饮酒与HPV16、18感染相关（P〈0.05）。结论：新疆不同民族HPV16、18总体感染率低于其他地区,不同民族HPV16、18感染率无统计学差异。吸烟、饮酒是舌体鳞状细胞癌HPV16、18感染的相关影响因素,饮酒是独立保护性因素。

Objective：To detect HPV16,18 in different nationalities in Xinjiang tongue squamous cell carcinoma expression rate,and explore the risk factors of the infection of HPV16,18.Methods：A retrospective analysis of 63 patients diagnosed as squamous cell carcinoma of the tongue in 2004June-2013 year in June,the First Affiliated Hospital of Xinjiang Medical University,using PCR technique for the detection of Xinjiang Uygur,Kazak,Han squamous cell carcinoma of the tongue,and the overall HPV16 18 subtype infection rate,and clinical and pathological data were collected in detail,and the research of HPV16,18 relative risk factors of the infection.Results：63cases of cancer of the body of tongue in patients with squamous cell,HPV16,18 overall infection rate was 28.6%.The HPV16 infection rate was 23.8%;the HPV18 infection rate was 7.9%;wherein HPV16 and HPV18cross infection in 2cases,1cases of Uigur and han.The Uygur patients with HPV16,18 of the overall infection rate was36.8%.Kazak patients with HPV16,18 of the overall infection rate was 10%.Han HPV16,18 of the overall infection rate was 29.4%.Single factor analysis showed：there was no significant difference in tongue squamous cell carcinoma patients with HPV infection and age,gender,nationality,site,and the smoking and drinking had significant difference（P〈0.05）.Multivariate Logistic regression analysis showed：drinking is related with HPV16,18infection（P〈0.05）.Conclusion：HPV16,18 overall infection rate of Xinjiang was lower than other regions.Different ethnic had no significant difference in infection rates.Smoking and alcohol consumption is tongue squamous cell carcinoma of the HPV16,18infection-related factors.Alcohol consumption is an independent protective factor.