点阵Er:YAG激光对小鼠皮肤胶原纤维及弹性纤维的影响

Effects of Er:YAG laser irradiation on the elastic fibers and collagenic fibers in mice

目的:评价不同能量点阵铒:钇铝石榴石(Er:YAG)激光对小鼠皮肤胶原纤维及弹性纤维的影响。方法:根据激光照射能量的不同将126只雌性昆明种小鼠分为高能量组(75 J/cm^2)、低能量组(43.8 J/cm^2)和对照组,观察每组不同时间皮肤组织学变化。结果:高能量组胶原纤维、弹力纤维数量及真皮厚度高于低能量组,但红斑水肿期延长;在接受激光照射后1个月内,胶原纤维、弹力纤维增加速度较快。结论:随着照射能量的增加,点阵(Er:YAG)激光对真皮层胶原及弹力纤维的增生刺激相应增强,但相应的副作用也随之增加。

Objective： To determine the effects of Er：YAG laser with different energies on the changes of elastic fibers and collagenic fibers in mice. Methods： One hundred and twenty-six mice were divided into the high-energy group （75 J/ cm2 ）, low-energy group（43.8 J/ cm2 ） and control group. Hematoxylin and eosin staining and EVG staining were performed to determine the changes of skin after laser irradiation. Results：The elastic fibers, collagenic fibers and the thickness of the dermis in high-energy group were higher than those in other groups, but the time of the erythema edema period was longer. The elastic fibers and collagenic fibers increased quickly within a month after laser irradiation. Conclusion： The elastic fibers and collagenic fi-bers increased along with the increase of laser energy, but the side effect increased accordingly.