转录因子Sp1表达与肝癌临床病理特征及预后的关系

Correlation of transcription factor Sp1 expression with clinical and pathological characteristics and prognosis of hepatocellular carcinoma

目的:通过研究肝癌组织内转录因子Sp1的表达及其与肝癌患者临床病理特征及预后的关系,探讨转录因子Sp1作为肝癌预后预测指标的可行性。方法:对98例根治性切除术的肝细胞肝癌肿瘤组织芯片进行免疫组化检测Sp1的表达情况,分析其与肝癌患者临床病理特征及预后之间的关系。结果:免疫组化结果显示Sp1在肝癌组织中表达明显高于对应正常肝脏组织,在有微血管侵犯的患者中升高尤其明显。进一步分析显示Sp1表达与肝癌患者术后总体生存率呈负相关,而与肝癌患者术后复发率呈正相关。结论:转录因子Sp1在肝癌中明显高表达,可作为肝癌患者预后的独立预测指标。

Objective： To explore the clinical significance of transcription factor Sp1 expression in hepatocellular carcinoma （HCC） and association between Sp1 expression and survival in HCC patients. Methods：With the use of immunoreactivity, Sp1 expres-sion and its correlation with other clinicopathological characteristics were examined in a tissue microarray that contains samples from 98 HCC patients. Results：HCC tissues expressed markedly higher levels of Sp1 than did adjacent normal liver tissues. Sp1 expression was closely associated with microvascular invasion, which suggests that HCC with more microvascular invasion is prone to have in-creased Sp1 expression. Overexpression of Sp1 correlates with significantly shorter overall survival and higher recurrence rates in HCC patients after curative resection. Conclusion：Transcription factor Sp1 may be an independent prognostic factor for both overall surviv-al and cumulative recurrence rate.