雷公藤内酯醇治疗过敏性哮喘实验研究进展

Progress in experimental research on allergic asthma treatment with triptolide

雷公藤内酯醇是从卫矛科植物雷公藤中提取的一种环氧二萜内酯类化合物,具有抗肿瘤、抗炎和免疫抑制等多种作用。雷公藤内酯醇能减轻气道高反应性,改善气道平滑肌增生和气道重构。雷公藤内酯醇对过敏性哮喘的治疗作用可能与其抑制树突状细胞成熟、缓解Th1/Th2失衡、减少炎症因子分泌、减轻嗜酸性粒细胞浸润以及降低炎症反应等有关。

Triptolide（TP）is a diterpenoid epoxide purified from a Chinese herb Tripterygiumwilfordii Hook. f.. lt has been shown to have multiple pharmacological activities,such as anti-tumor,anti-inflammatory,immune-suppressive effects. TP can reduce airway hyperresponsiveness,decrease the proliferation of airway smooth muscle,and produce potential therapeutic effect in airway remodeling. The effect of TP on allergic asthma may be related to its inhibition of maturation of dendritic cells,rebalance of the function of Th1 and Th2,reduction of the secretion of inflammatory factors,and decrease of the infiltration of eosinophils.