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Notch信号通路对胶质瘤干细胞的调控作用研究进展 被引量：3

Advance on the mechanism of Notch signaling pathway regulation on glioma stem cells
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摘要 胶质瘤干细胞(GSCs)是胶质瘤放化疗耐受和复发的重要原因。而Notch信号通路对GSCs形成、维持及胶质瘤患者放化疗耐受中起关键的调控作用。因此,深入研究GSCs中Notch信号通路调控机制对开发以该通路为靶向的治疗药物具有积极意义。 Glioma stem cells play a crucial role in glioma recurrence and resistance to radio-and chemotherapy.Notch signaling pathway was involved in glioma stem cells＇ forming and maintaining.Moreover,Notch activation was contributed to chemotherapy and radiotherapy of resistance in glioma.Therefore,the study on Notch signaling pathway of glioma stem cells significantly facilitating the development of targeted treatment.
作者 陈声波 刘子豪 杜彬
机构地区 暨南大学医学院病理教研室
出处 《基础医学与临床》 CSCD 北大核心 2014年第11期1566-1569,共4页 Basic and Clinical Medicine
基金 国家自然科学基金(31201028) 暨南大学大学生创新创业训练计划(1055912177) 广东省医学科研基金(A2011328)
关键词 NOTCH信号 胶质瘤干细胞 抗治疗 干细胞维持 Notch signaling pathway glioma stem cells anti-therapy stem cell maintenance
分类号 R739.41 [医药卫生—肿瘤]
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参考文献24

  • 1Kopan R.Notch signaling[J].Cold Spring Harb Perspect Biol,2012,4:1-4.
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同被引文献50

  • 1于春泳,尹昌林,吕胜青,杨辉.NOTCH-1信号通路对人脑胶质瘤干细胞增殖和分化作用的研究[J].中国微侵袭神经外科杂志,2008,13(6):268-272. 被引量：4
  • 2范存刚,张庆俊.肿瘤坏死因子相关凋亡诱导配体治疗脑胶质瘤的研究进展[J].肿瘤防治研究,2014,41(2):168-172. 被引量：7
  • 3Wang MM. Notch signaling and Notch signaling modifiers [J]. Int J Biochem Cell Biol, 2011, 43:1150-1562.
  • 4Hsu HJ, Drummond-Barbosa D. Insulin signals control the competence of the Drosophila female germline stem cell niche to respond to Notch ligands [J]. Dev Biol, 2011, 350 : 290-300.
  • 5Chen HJ, Wang CM, Wang TW, et al. The Hippo pathway controls polar cell fate through Notch signaling during Dro- sophila oogenesis [J]. Dev Bid, 2011, 357: 370-379.
  • 6Chen CL, Fu XF, Wang LQ, et al. Primordial follicle as- sembly was regulated by Notch signaling pathway in the mice [J]. Mol Biol Rep, 2014, 41: 1891-1899.
  • 7Jovanovic VP, Sauer CM, Shawber C J, et al. Intraovarian regulation of gonadotropin-dependent folliculogenesis de- pends on notch receptor signaling pathways not involving Delta-like ligand 4 ( Dl14 ) [ J ]. Reprod Biol Endocfinol, 2013, 11 : 43. doi: 10. 1186/1477-7827-11-43.
  • 8Xu J, Gridley T. Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of pri- mordial follicles [J]. BMC Biol, 2013, 11 : 13. doi: 10. 1186/1741-7007-11-13.
  • 9Manosalva I, Gonzalez A, Kageyama R. Hesl in the somat- ic ceils of the murine ovary is necessary for oocyte survival and maturation [J]. Dev Biol, 2013, 375: 140-151.
  • 10Raafat A, Goldhar AS, Klauzinska M, et al. Expression of Notch receptors, hgands and target genes during devel- opment of the mouse mammary gland [ J ]. J Cell Physiol, 2011,226: 1940-1952.

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基础医学与临床
2014年 第11期

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