依托咪酯和丙泊酚分别用于乳腺包块切除手术的临床观察

Comparison of anesthesia with etomidate and propofol for breast lumpectomy

目的:观察依托咪酯和丙泊酚在乳腺良性包快切除手术中的麻醉效果和不良反应。方法:132例乳腺良性包快切除术的患者随机分为依托咪酯组和丙泊酚组。两组同时持续静脉注射瑞芬太尼及利多卡因局部麻醉。观察生命体征、术后苏醒时间及不良反应。结果:两组术中呼吸频率均有减慢,丙泊酚组更明显(P<0.05)。术中心率丙泊酚组较依托咪酯组低,但无统计学意义(P>0.05)。术中平均动脉压丙泊酚组明显降低(P<0.05)。丙泊酚组术中血氧饱和度降低较依托咪酯组明显(P<0.05)。两组苏醒时间及不良反应发生率无明显差异(P>0.05)。结论:两组麻醉效果满意,依托咪酯对呼吸循环功能的影响较小,更适用于此类短小手术的麻醉。

Objective：To compare the anesthesia effect and adverse reaction of etomidate and propofol for breast lumpectomy of benign masses. Methods： A total of 132 patients undergoing resection of breast benign lesions were randomly divided into etomidate group （n = 66） and propofol group （n = 66）. All patients received intravenous injection of remifentanil and local anesthesia with lidocaine. The vital sign, postoperative palinesthesia time and adverse reaction were observed. Results： Compared with etomidate group,the intraoperative breathing rate in propofol group was obviously slower （P〈0.05）,the heart rate was lower （P〉0.05） ,and the mean arterial pressure and blood oxygen saturation were significantly lower （P〈0.05）. There were no significant differences in palinesthesia time and adverse reaction between two groups （P〉0.05）. Conclusion： The anesthesia effect in two groups is satisfactory. The etomidate is more suitable for breast local resection bdue to less effect on respiratory and circulatory function.