安非他酮与西酞普兰治疗老年期抑郁症对照研究

A Control Study of Bupropion and Citalopram in the Treatment of Depression

目的观察安非他酮缓释片治疗老年期抑郁症的临床疗效和安全性。方法进行6周的开放式前瞻性随机对照研究,将56名老年期障碍的患者随机分为两组,安非他酮组（26例）和西酞普兰组（30例）,疗程6周,采用汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）及副反应量表（TESS）在治疗前和治疗后1、2、4、6周末评定药物疗效和副反应。结果采用t检验,两组HAMD和HAMA总分及各因子分从疗后2~6周均较治疗前显著降低（t=20.45,13.50,6.7,6.06;P均〈0.01）,两组间无显著性差异;治疗结束时TESS评分安非他酮组与西酞普兰组无显著性差异（t=0.23,P〉0.05）。结论安非他酮缓释片治疗老年期抑郁症的疗效及药物不良反应均与西酞普兰相当,可作为治疗老年期抑郁症的一线药物使用。

ObjectiveTostudytheefficacyandsafetyofbupropioninthetreatmentofdepression.Methods 56depressedelderly patients were randomized into bupropion group （n=26）and citalopram（n=30）,and studied for 6 weeks.HAMD,HAMA and TESS were used to assess the efficacy and side effects before and 1 week,2 weeks,4 weeks and 6 weeks after the treatment .Results There was no significant difference in efficacy between two groups .HAMD scores and factor scores from 2 weeks to 6 weeks decreased dramatically as compared to pretreatment ,no significant difference was observed between two groups .After the trial,the TESS scores in bupropion group were no significant differences from citalopram group .Conclusion Bupropion is an effective ,convenient and safe in the treatment of eld-erly depression .It has few side effects and can be a first drug choice.