重性抑郁症患者睡眠脑电特征与短期疗效的关系

The Relationship between Polysomnographic Features and Short-term Therapeutic Effect in Patients with Major Depression

目的研究重性抑郁症患者睡眠脑电特征与短期疗效的关系。方法按照入组标准和排除标准纳入重性抑郁症患者共29例,对抑郁症患者在入组时进行睡眠脑电测试,并应用汉密尔顿抑郁(HAMD)量表评估抗抑郁治疗4周的疗效(短期疗效)。结果 1短期治疗有效的患者组入组时睡眠潜伏期与短期治疗无效的患者组相比有显著性差异(t=2.649,P<0.05);2重性抑郁症患者睡眠脑电睡眠潜伏期与ΔHAMD变化值成正相关(r=0.378,P<0.05),觉醒总时间与ΔHAMD变化值成正相关(r=0.493,P<0.05),睡眠效率与ΔHAMD变化值成负相关(r=-0.446,P<0.05),睡眠维持与ΔHAMD变化值成负相关(r=-0.427,P<0.05)。结论重性抑郁症患者的某些睡眠特征如睡眠潜伏期、睡眠效率等能够预测不同的短期疗效。

Objective To investigate the relationship between polysomnographic features and short -term therapeutic effect in pa-tientswithmajordepression.Methods 29patientswithmajordepressionwererecruitedinthestudy.Sleepcharactersweremeasuredin 29 MDD patients by Polysomnography（PSG）equipment,and therapeutic effect（4 weeks short -term effect）were evaluated by HAMD. Results ①Therewasstatisticalsignificantdifferenceinsleeplatencybetweeneffectivepatientsgroupandnoeffectivepatientsgroup（t=2.649,P〈0.05）.②Some aspects such as sleep latency ,awakening time,sleep efficiency and sleep maintenance in Polysomnography were correlated with the change of HAMD （ΔHAMD）in major depression（r=0.378,0.493,-0.446,-0.427;P〈0.05）.Conclusion Some characters of sleep electroencephalogram can predict therapeutic effect in major depression .