帕罗西汀合并加巴喷丁治疗躯体形式障碍对照研究

Paroxetine Combined with Gabapentin in the Treatment of Somatoform Disorder

目的探讨帕罗西汀合并加巴喷丁治疗躯体形式障碍的疗效及安全性。方法 86例躯体形式障碍患者随机分为两组,研究组帕罗西汀合并加巴喷丁进行治疗,对照组单用帕罗西汀,疗程8周。治疗前及治疗后2、4、6、8周末分别应用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、症状自评量表(SCL-90)躯体化因子评定临床疗效,用副反应量表(TESS)评定不良反应。结果治疗后2、4、6、8周末研究组HAMD、HAMA、SCL-90躯体化因子评分与对照组有显著性差异(P<0.01)。8周末研究组显效率76.74%,对照组显效率55.81%,研究组显效率高于对照组(χ2=4.214,P<0.05)。不良反应均较轻,两组间比较无显著性差异。结论帕罗西汀合并加巴喷丁治疗躯体形式障碍的疗效优于单独应用帕罗西汀,且疗效出现较早,副作用无明显增加。

Objective To explorer the efficacy and safety of paroxetine combined with gabapentin in the treatment of somatoform dis -order.Methods A total of 86 patients with somatoform disorder were randomly divided into two groups ,study group with paroxetine com-bined with gabapentin and control group with proxetine for the treatment of 8 weeks.The efficacy was assessed with Hamilton Depression Rating Scale（HAMD）,Hamilton Anxiety Rating Scale（HAMA）,Symptom Checklist-90（SCL-90）and side effect were assessed with Treatment Emergent Symptom Scale（TESS）at the beginning and the end of 2th,6th,4th and 8th week of the treatment.Results There were significant differences in the factor score of somatoform in SCL -90,total score of HAMD,HAMA between two groups at the end of 2th,4th,6th and 8th week of the treatment（P＜0.01）.The effective rate in the study group was significantly higher than that in the con-trol group（76.74%vs 55.81%;χ2 =4.214,P＜0.05）.The side effects were mild and there were no significant difference between the two groups .Conclusion Paroxetine combined with gabapentin is better than paroxetine in the treatment of somatoform disorder and less side effects.