血管内皮生长因子在缺血性脑卒中的研究进展

Advancement in Studies on Vascular Endothelial Growth Factor in Ischemic Stroke

血管内皮生长因子(VEGF)是一个还在不断增加的内皮细胞生长因子家族的创始成员之一。VEGF是胚胎发育过程中骨骼生长和生殖功能生理性血管生成的关键。VEGF是治疗局部缺血性疾病的潜在血管生成蛋白。VEGF发挥神经保护作用,并促进神经发生和脑血管发生,但这些效应在脑缺血中的互相作用知之甚少。该文就VEGF在生理性、病理条件下血管生成中的作用和治疗意义与前景予以综述。

Vascular endothelial growth factor（VEGF） is one of the initial members of a still growing family of endothelial cell growth factors. VEGF is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF is an angiogenic protein with therapeutic potential in ischemic disorders,including stroke. VEGF confers neuroprotection and promotes neurogenesis and cerebral angiogenesis,but the manner in which these effects may interact in the ischemic brain is poorly understood. Here is to make a review of the role of VEGF in physiological angiogenesis pathological conditions, and its therapeutic implications and perspectives.