子宫颈癌新辅助化疗的研究进展

Research Progress of Neoadjuvant Chemotherapy for Cervical Cancer

子宫颈癌是女性生殖系统最常见的恶性肿瘤。近年来,子宫颈癌的发病率呈升高和低龄化趋势。子宫颈癌传统的治疗方法为手术、放疗、手术加放疗。局部病灶直径>4 cm及Ⅱb以上者均需放疗,但复发率高,且放疗并发症较多,尤其对年轻患者的卵巢及阴道功能影响较大,严重影响患者生活质量。合理的新辅助化疗不仅可消灭微小转移灶,还可以缩小肿瘤体积和范围,提高手术或放疗效果,对保护卵巢及阴道功能有益。

Cervical cancer is the most common malignant tumor in female genital system. In recent years ,the incidence of cervical cancer is higher and the patients tend to be younger. Traditional treatments for cervical cancer are surgery, radiation therapy, and surgery plus radiotherapy. Radiotherapy is required for local lesion diameter greater than 4 cm and phase Ⅱ b above, but the recurrence rate is high, and complications of radiotherapy are more seriously affecting the quality of life of patients, especially on the ovarian and vaginal function of younger patients. In recent years, some studies show that a reasonable neoadjuvant chemo- therapy not only can eliminate micrometastases, but also can reduce the tumor size and scope to improve the effect of surgery or radiotherapy, which is beneficial for ovarian and vaginal function protection.